Related Products of 288-32-4, The chemical industry reduces the impact on the environment during synthesis 288-32-4, name is 1H-Imidazole, I believe this compound will play a more active role in future production and life.
A solution of 68 g of imidazole in 250 cm3 of dimethylformamide was added over 30 minutes to a suspension of 30 g of sodium hydride (at 50% in mineral oil) in 250 cm3 of dimethylformamide. The mixture was stirred for 90 minutes at a temperature in the region of 20 C. and then a solution of 50.5 g of 2-chloroethanol in 50 cm3 of dimethylformamide was added over one hour. The mixture was stirred for 12 hours at a temperature in the region of 20 C. and then filtered. The filtrate was treated with 100 cm3 of distilled water and then concentrated under reduced pressure (2.7 kPa) at a temperature in the region of 55 C. The pasty residue was taken up in 150 cm3 of petroleum ether, the liquid phase was separated by settling and the residue was triturated for one hour with 100 cm3 of isopropanol. The precipitate formed was filtered off and the filtrate was concentrated under reduced pressure (2.7 kPa) at a temperature in the region of 40 C. The residual oil (113.1 g) was distilled under reduced pressure (5 kPa) and resulted in 105.7 g of 2-hydroxy-(1-imidazolyl)ethane in the form of a yellow oil that distilled at a temperature of 180-183 C. at 5 kPa.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1H-Imidazole, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Rhone-Poulenc Rorer, S.A.; US5965527; (1999); A;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem