Related Products of 93-84-5,Some common heterocyclic compound, 93-84-5, name is 5-Nitro-1H-benzo[d]imidazol-2(3H)-one, molecular formula is C7H5N3O3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Concentrated hydrochloric acid (5 drops) was added to a suspension of 5-nitro-1, 3-dihydrobenzimidazol-2-one (intermediate 10,0. 96g) in phosphorus oxychloride (25ml) and the mixture was stirred and heated at reflux for 7h. The cooled mixture was poured into a mixture of ice and water and the precipitated product was extracted into ethyl acetate. The organic phase was dried (MgSO4), filtered and the filtrate was evaporated to give 2-chloro-5-nitrobenzimidazole as a tan coloured solid (0.9g). ‘H NMR (DMSO-d6) d 14.0 (brs, 1H) 8.45 (brs, 1H) 8.15 (d, 1H) 7.7 (d, 1H)
The synthetic route of 93-84-5 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; ARGENTA DISCOVERY LTD.; WO2005/35526; (2005); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem