Month: June 2021

Related Products of 39021-62-0, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 39021-62-0, name is 1-Methyl-1H-imidazole-5-carbaldehyde, This compound has unique chemical properties. The synthetic route is as follows.

A 20 mL vial equipped with a stir bar was charged with the recovered amine 62 and product mixture (0.330 mmol, 1 equiv.), 43.3 mg of l-methyl-lH-imidazole-4-carbaldehyde (0.390 mmol, 1.2 equiv.), 0.019 mL of CH3COOH (0.330 mmol, 1 equiv.) and 3.4 mL of CH2CI2 and stirred at rt for 3 h. Then 111 mg of NaBH(OAc)3 (0.520 mmol, 1.6 equiv.) was added. After stirring at rt for 12 h, the reaction mixture was quenched by addition of sat. NaHCCb solution and sat. Na2CCb sol., and the product was extracted with CH2CI2 (3x) and dried over Na2S04. The crude product was purified on silica gel column (12 g) using 0-30 % MeOH in EA as eluent affording 116 mg (43%) of N-((S)-3-((R)-3-(((4-(l,3-dioxoisoindolin-2-yl)butyl)((S)-5,6,7,8-tetrahydroquinolin-8- yl)amino)methyl)-4-((1 -methyl- lH-imidazol-5-yl)methyl)piperazin- 1 -yl)- 1 -phenylpropyl)-4,4- difluorocyclohexane-l -carboxamide 78 as a yellowish foam.

The chemical industry reduces the impact on the environment during synthesis 1-Methyl-1H-imidazole-5-carbaldehyde. I believe this compound will play a more active role in future production and life.

Reference:
Patent; EMORY UNIVERSITY; LIOTTA, Dennis C.; JECS, Edgars; ALTAS TAHIROVIC, Yesim; WILSON, Lawrence; PELLY, Stephen Christopher; (102 pag.)WO2019/183133; (2019); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 6160-65-2 as follows. Computed Properties of C7H6N4S

To a suspension of 4-bromo-3-chloro-5-(trifluoromethyl)aniline (15 g, 54.7 mmol, Eq: 1.00) in dichloromethane (13.2 g, 10.0 ml, 155 mmol, Eq: 25.3) at 0, was added 1,1′- thiocarbonyldiimidazole (11.7 g, 65.6 mmol, Eq: 1.2) The reaction was gradually warmed to room temperature and stirred overnight. The reaction was concentrated and chromatographed (220g Redisep, 5 to 15% dichloromethane/hexane) to give 13.84 g (80%) pale yellow oil.

According to the analysis of related databases, 6160-65-2, the application of this compound in the production field has become more and more popular.

Reference:
Patent; F. HOFFMANN-LA ROCHE AG; HOFFMANN-LA ROCHE INC.; DING, Qingjie; JIANG, Nan; WEIKERT, Robert James; WO2014/135422; (2014); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Related Products of 1402838-08-7, The chemical industry reduces the impact on the environment during synthesis 1402838-08-7, name is 2-(1-Trityl-4-imidazolyl)benzaldehyde, I believe this compound will play a more active role in future production and life.

Compound 4 (196 mg, 0.51 mmol) was dissolved in 10 mL of anhydrous tetrahydrofuran, and 30.5 mg of sodium hydride was added on an ice bath, and the mixture was warmed to room temperature and stirred for 1 hour. A solution of compound 4a (211 mg, 0.51 mmol) in 5 mL of anhydrous tetrahydrofuran was added to the reaction flask in an ice bath. The mixture was warmed to room temperature, stirred overnight, quenched with saturated ammonium chloride, added with 100 mL of water and extracted with dichloromethane (50 mL×3). The combined extracts were washed with saturated brine, dried over anhydrous sodium sulfate and evaporated to dryness under reduced pressure. The crude product was purified by column chromatography to give Compound 5 (134 mg, yield 39%).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-(1-Trityl-4-imidazolyl)benzaldehyde, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Lunan Pharmaceutical Group Co., Ltd.; Zhang Guimin; (92 pag.)CN107488179; (2017); A;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Adding a certain compound to certain chemical reactions, such as: 22884-10-2, name is 2-(1H-Imidazol-1-yl)acetic acid, belongs to imidazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 22884-10-2, Product Details of 22884-10-2

Step 1: methyl 14-cyclohexl-3-fluoro-6-( 1 H-imidazol-1 -ylacetyl)-5.6,7,8-tetrahydroindolo[2.] -a] (2,5 lbenzodiaz.ocine-11 -carboxylate; To a solution of 1 eq of methyl-14-cyclohexyl-3-fluoro-5,6,7,8-tetrahydroindolo[2,l- a][2,5]benzodiazocin-l 1-carboxylate (prepared as described in Example 18, Step 5 ) in DCM (0.06 M), 1.1 eq of imidazo-1-yl acetic acid in DCM (0.05 M), 3 eq of DIPEA and 1.5 eq of TBTU were added and the mixture stirred at RT overnight. Volatiles were removed in vacuo and the crude material was used in the next step without further purification; MS (ES+) m/z 515 (M+Eta)+. EPO Step 2: 14-cyclohexyl-3-fluoro-6-(lH-imidazol-l-ylacetyl)-5.6.7,8-tetrahydroindolof2.1- alf2.5 Ibenzodiazocine- 11 -carboxylic acid

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-(1H-Imidazol-1-yl)acetic acid, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P ANGELETTI SPA; WO2006/46030; (2006); A2;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Reference of 3314-30-5,Some common heterocyclic compound, 3314-30-5, name is 1H-Benzo[d]imidazole-2-carbaldehyde, molecular formula is C8H6N2O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: A flask was equipped with a magnetic stir bar and charged with 1Hpyrrole-2-carbaldehyde (2a; 19.0 mg, 0.2 mmol, 1.0 equiv), 2-bromophenylacetonitrile(1a; 39.2 mg, 0.2 mmol, 1.0 equiv), and K3PO4(63.6 mg, 0.3 mmol, 1.5 equiv). The flask was evacuated and filledwith N2, and then anhydrous DMSO (2.0 mL) was introduced via a syringe.The flask was heated in a 130 °C oil bath for 24 h, at which timeTLC analysis [petroleum ether (bp 60?90 °C)?EtOAc, 10:1] indicatedcomplete consumption of 2a and 1a. The reaction mixture was cooledto r.t. and added to a sat. solution of NaCl (20 mL) and extracted withEtOAc (3 × 10 mL). The combined organic layers were dried (Na2SO4)and filtered. The filtrate was concentrated, and the residue was purified by column chromatography on SiO2 [petroleum ether (bp 60?90°C)?EtOAc, 10:1 to 30:1] to give 3ai; Yield: 19.9 mg (41percent); tan solid; mp 251.7?252.8 °C.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1H-Benzo[d]imidazole-2-carbaldehyde, its application will become more common.

Reference:
Article; Jiang, Zeng-Qiang; Miao, Da-Zhuang; Tong, Yao; Pan, Qiang; Li, Xiao-Tong; Hu, Ren-He; Han, Shi-Qing; Synthesis; vol. 47; 13; (2015); p. 1913 – 1921;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 570-22-9, name is 1H-Imidazole-4,5-dicarboxylic acid, A new synthetic method of this compound is introduced below., Safety of 1H-Imidazole-4,5-dicarboxylic acid

General procedure: Ethane-1,2-diamine (4a; 60mg; 1mmol) and iminodiacetic acid (5; 266mg; 2mmol) were mixed thoroughly, grinded and subjected to focused microwave irradiation at 135 C for 4 minutes. TLC of reaction mixture over silica gel G using ethyl acetate: MeOH (7:3) as mobile phase showed that the reaction is complete. Crude product, so obtained was purified by crystallization from methanol: water (9.5:0.5) to give pure product 9a. Yield: 83%.

The synthetic route of 570-22-9 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Kumar, Anuj; Banerjee, Somesh; Roy, Partha; Sondhi; Sharma, Anuj; Bioorganic and Medicinal Chemistry Letters; vol. 27; 3; (2017); p. 501 – 504;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 60-56-0, name is 1-Methyl-1H-imidazole-2(3H)-thione, This compound has unique chemical properties. The synthetic route is as follows., Safety of 1-Methyl-1H-imidazole-2(3H)-thione

General procedure: To a stirred suspension of potassium carbonate (0.166 g, 1.2mmol) in ethanol (8 mL) was added 1H-imidazole (0.068 g,1 mmol). The mixture was stirred at 60 C for 1 h and thencooled to room temperature. Compound 3 (0.232 g, 1 mmol)was added and stirred under 70 C. After the reaction wascompleted (monitored by TLC, chloroform/methanol, 30:1,V/V), the solvent was evaporated and the residue was treatedwith water (15 mL) and extracted with chloroform (315mL). The combined organic phase was dried over anhydroussodium sulfate and concentrated under the reduced pressure.The crude product was purified by silica gel column chromatography(eluent, chloroform/methanol, 50:1-30:1, V/V)to afford the pure compound 4a (0.142 g) as white solid

According to the analysis of related databases, 60-56-0, the application of this compound in the production field has become more and more popular.

Reference:
Article; Peng, Xin-Mei; Kumar, Kannekanti Vijaya; Damu, Guri L.V.; Zhou, Cheng-He; Science China Chemistry; vol. 59; 7; (2016); p. 878 – 894;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

75370-65-9, name is 4-Amino-1H-benzo[d]imidazol-2(3H)-one, belongs to imidazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. SDS of cas: 75370-65-9

Amine 2bf (1.1 g, 6.7 mmol) was dissolved in 40ml of AcOEt and at0C triphosgene (1.93 g, 6.7 mmol) was added to the solution. The mixture was warmed at 80C for 4 hours then evaporated and the residue was dissolved in 15ml of DMF. The solution of the isocyanate was added dropwise to a solution in DMF (10 ml) of compound la (1 g, 6.7 mmol) and the mixture was warmed at 80C for 8 hours. (TLC AcOEt 9.5 / MeOH 0.5). The solvent was evaporated and the crude was dissolved in AcOEt (50 ml) and washed with water (1 X 30 ml) and brine. The organic phase was dried over sodium sulfate and concentrated under vacuum. The purification of the crude residue by chromatographic column gave 450 mg of a pale yellow solid. Yield = 19% ‘HNMR (DMSO, 200 MHz) delta 2.26 (3H, s), 2.59 (6H, m), 4.33 (2H, d, J = 5.6 Hz), 6.60 (2H, m), 6.87 (4H, m), 7.18 (1H, d, J = 7.6 Hz), 8.28 (1H, s), 9.96 (1H, bs), 10.60 (1H, bs); [M+1] 339.56 (C18H21N5O2 requires 339.39).

The synthetic route of 75370-65-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; PHARMESTE S.R.L.; NAPOLETANO, Mauro; TREVISANI, Marcello; PAVANI, Maria Giovanna; FRUTTAROLO, Francesca; WO2011/120604; (2011); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 1072-62-4 as follows. SDS of cas: 1072-62-4

EXAMPLE 2 2-Ethyl-4,5-dihydroxymethylimidazole The procedure described in Example 1 is followed, except that 96 g (1 mole) of 2-ethylimidazole are used instead of 2-methylimidazole. The 155 g of crude product obtained in this procedure are stirred with 52 g of methanol for 30 minutes at 50 C. and at 10 C. with cooling. The mixture is filtered, the product is washed with twice 150 ml of acetone and dried in a drying oven, and 117.5 g of 2-ethyl-4,5-dihydroxymethylimidazole of melting point 173.35-174.0 C. are obtained. This corresponds to a yield of 75.4%. The purity of this sample is 99.8% according to HPLC. Elemental analysis: Mass spectrum: M+ 156. 1 H-NMR spectrum (solvent DDMSO) 1.15 (t, 1p) 2.55 (q, 2p) 4.4 (s, 4p).

According to the analysis of related databases, 1072-62-4, the application of this compound in the production field has become more and more popular.

Reference:
Patent; BASF Aktiengesellschaft; US4658035; (1987); A;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 35203-44-2, name is 1-Propyl-1H-imidazole, This compound has unique chemical properties. The synthetic route is as follows., Quality Control of 1-Propyl-1H-imidazole

Part of the trans-[RuCl4(DMSO)2]Na 0.10g (0.24mmol) prepared in Example 1 was dissolved in acetone andTo 0.33 ml of dimethyl sulfoxide, 0.14 ml (1.23 mmol) of N-propylimidazole was further added. The ultrasonic reaction was carried out for 2 hours. The reaction liquid was filtered, and a mixture of chloroform and diethyl ether was added to the filtrate to cause crystallization. The crystals were filtered, washed with a mixture of chloroform/diethyl ether (v/v = 1:9) and dried over silica gel to give the desired product G99. Yield: 70percent.

According to the analysis of related databases, 35203-44-2, the application of this compound in the production field has become more and more popular.

Reference:
Patent; China Zhongyi Academy Of Sciences Traditional Chinese Medicine Institute; Beijing Tangshi Traditional Chinese Medicine Research Center; Gu Liwei; Liang Yaohua; Li Canghai; Shen Jianying; Liang Guogang; Jiang Tingliang; Li Xiaodong; (16 pag.)CN104744518; (2018); B;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem