Reference of 137049-00-4, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 137049-00-4 name is 1-Methyl-1H-imidazole-4-sulfonyl chloride, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
Example 144 (+-)-N-Benzyl-trans-3,4-dimethyl-4-(3-(1-methyl-1H-imidazole-4-sulfonylamino)phenyl)piperidine To a solution of (+-)4-(3-aminophenyl)-N-benzyl-trans-3,4-dimethylpiperidine (Preparation 9, 500 mg, 1.706 mmol) in pyridine (7 ml) under nitrogen was added 1-methyl-1H-imidazole-4-sulfonyl chloride (462 mg, 2.56 mmol), and the resultant mixture was stirred for 52 h before hydrolysing with ice (10 g). The reaction mixture was concentrated in vacuo at 80 C. and the residue was taken up in dichloromethane (200 ml), washed with saturated aqueous sodium hydrogen carbonate solution (70 ml), dried (Na2SO4), filtered and concentrated in vacuo to give the crude product. This was purified by silica (10 g) column chromatography eluding with ethyl acetate:triethylamine (99:1) to give the title compound as a white solid (640 mg, 86%). NMR (CDCl3, selected data for the free base): 0.5 (d, 3H), 1.1 (s, 3H), 3.6 (s, 3H), 6.8-7.4 (m, 11H). MS (thermospray): M/Z [MH+] 439.1; C24H30N4O2S+H requires 439.2.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1-Methyl-1H-imidazole-4-sulfonyl chloride, and friends who are interested can also refer to it.
Reference:
Patent; Armer, Richard Edward; Dutton, Christopher James; Gethin, David Morris; Gibson, Stephen Paul; Smith, Julian Duncan; Tommasini, Ivan; US2003/78282; (2003); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem