Synthetic Route of 137049-00-4, A common heterocyclic compound, 137049-00-4, name is 1-Methyl-1H-imidazole-4-sulfonyl chloride, molecular formula is C4H5ClN2O2S, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Step 4A: To a stirred solution of (3i?)-l-[4-fluoro-2-(trifluoromethyl)phenyl]-3- methylpiperazine (1.038 g, 3.96 mmol) and diisopropylethylamine (1.38 rnL, 7.92 mmol) in anhydrous dichloromethane (15 rnL) was added 1 -methyl- lEta-imidazole-4-sulfonyl chloride (0.715 g, 3.96 mmol) at O0C. The mixture was stirred at O0C for 30 min, then stirred at room temperature for o/n. The reaction mixture was washed with H2O, extracted with DCM. The organic layer was dried over Na2SO4 and concentrated. The crude product was purified via flash column chromatography, eluting with 2-4% MeOH/DCM to yield (2i?)-4-[4-fluoro-2-(trifluoromethyl)phenyl]-2-methyl-l-[(l- methyl-lH-imidazol-4-yl)sulfonyl]piperazine as a light yellow solid (1.22 g, 75.8% yield).
The synthetic route of 137049-00-4 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; WYETH LLC; WAN, Zhao-Kui; CHENAIL, Eva; IPEK, Manus; LI, Huan-Qiu; MANSOUR, Tarek, Suhayl; SURI, Vipin; XIANG, Jason, Shaoyun; SAIAH, Eddine; WO2010/141550; (2010); A2;,
Imidazole – Wikipedia,
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