Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 17325-26-7, name is Methyl 1H-imidazole-5-carboxylate, A new synthetic method of this compound is introduced below., Safety of Methyl 1H-imidazole-5-carboxylate
[0174] A solution of compound 12 (18.0 g, 142.7 mmol, 1.0 eq) and hydrazine hydrate (35.7 g, 713.7 mmol, 5.0 eq) in EtOH (200 mL) was stirred at 90 C for 15 h. After cooling to room temperature, a precipitate formed. The solid was filtered, and dried under vacuum to afford compound 13 (15.0 g, 119 mmol, 83% yield) as a white crystalline solid: 1H NMR (400 MHz, DMSO-d6) 6 4.35 (br. s., 2H) 7.61 (s, 1H) 7.72 (d, J=0.88 Hz, 1H) 9.10 (br. s., 1H) 12.49 (br. s., 1H).
The synthetic route of 17325-26-7 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; ZENITH EPIGENETICS CORP.; BROWN, Samuel, David; COBURN, Craig, Alan; KHARENKO, Olesya; (103 pag.)WO2016/92375; (2016); A1;,
Imidazole – Wikipedia,
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