Reference of 144689-93-0,Some common heterocyclic compound, 144689-93-0, name is Ethyl 4-(1-hydroxy-1-methylethyl)-2-propylimidazole-5-carboxylate, molecular formula is C12H20N2O3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Example 1; Ethyl 4-( 1 -hydroxy- 1 -methylethyl)-2-propyl- 1 – { 4- [2-(tetrazol-5-yi)phenyl]phenyl}methyl- imidazole-5-carboxylate (3); Acetone (200 ml) was added to the weighed ethyl ester of 4-(l -hydroxy- l-methylethyl)-2- propyl-lH-imidazole-5-carboxylic acid (1; 20 g), substance 2 (46.4 g), potash (40 g), and polyethylene glycol 400 (2 g). The resulting mixture was heated to the boil for H h. After filtering off the solids the filtrate was concentrated, ethanol (350 ml) was added to the concentrated filtrate, and the suspension was heated to the boil. After it was cooled to 15 C (20 minutes), the insoluble portion was sucked off and washed with ethanol (40 ml). After drying (50 0C, in vacuo), 50.7 g of the product (85 %) was obtained.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Ethyl 4-(1-hydroxy-1-methylethyl)-2-propylimidazole-5-carboxylate, its application will become more common.
Reference:
Patent; ZENTIVA, A.S.; WO2007/48361; (2007); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem