Electric Literature of 2620-76-0, These common heterocyclic compound, 2620-76-0, name is 2-(4-Bromophenyl)-1-phenyl-1H-benzoimidazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
3- (4,6-diphenyl-1,3,5-triazin-2-yl) phenylboronic acid (10.0g, 0.028mol) in 2- (4-bromophenyl) -1-phenyl-1H-benzo [d] imidazole (8.0g, 0.023mol), Pd (PPh3) 4 (1.3g, 0.0011mol), into the THF in 400ml potassium carbonate (9.5g, 0.069mol) was reacted with stirring for 18 hours at 65 . After the reaction cooled to H20: After layer separation the MC column purification (n-Hexane: MC) to afford 85 12.1g (75percent yield).
The synthetic route of 2620-76-0 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; PH Tech Pvt. Ltd.; Hyeon, Seo Young; Yun, Young Ho; Kim, Tae Hwan; Oh, Hyeon Jin; (36 pag.)KR101593465; (2016); B1;,
Imidazole – Wikipedia,
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