In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 16681-56-4 as follows. Computed Properties of C3H3BrN2
Obtained in Example 50 (a) (S) -1-tert- butoxycarbonylamino-4- (5-chloro-7- (4,4,5,5-dioxa -1,3,2- borane-2-yl)benzoxazol-2-yl) -3-methyl piperazine (48 mg, 0.1mmol), 2- bromo -1H- imidazole (29 mg, 2.0 eq.), Tetrakis(triphenylphosphine) palladium (0) (11.6 mg, 0.1 eq), potassium carbonate (55 mg, 4.0 equiv) 1, 4-dioxane (800muL) and water (200muL) for dissolution, and under an argon atmosphere in an oil bath from 110 4 hours with stirring did. Water was added to the reaction mixture, the product extracted with ethyl acetate, an organic layer was washed with saturated aqueous sodium chloride. The organic layer was dried over anhydrous sodium sulfate, the solvent was distilled off under reduced pressure, and the residue was purified by preparative TLC (developing solvent, methanol: chloroform = 1: 19) to give the title compound 21.3 mg.
According to the analysis of related databases, 16681-56-4, the application of this compound in the production field has become more and more popular.
Reference:
Patent; MeijiSeika Pharma Corporation; Kikuchi, Jika; Tabata, Yuji; Yamakawa, Takeru; Matsuhira, Takashi; Watanabe, Naoko; Kuboda, Natsuki; Kaneda, Kaoru; (143 pag.)KR2016/30503; (2016); A;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem