In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 705-09-9 as follows. category: imidazoles-derivatives
Step d): 6-(4-chloro-6-(2-(difluoromethyl)-1 H-benzorc l imidazol-1 -yl)-1 ,3,5-triazin-2-yl)-2- oxa-6-azaspiro[3.31 heptane (22).Under nitrogen atmosphere an oven-dried round-bottom flask was charged with compound 21 (73.0 mg, 295 muiotatauiotaomicronIota, 1 .0 eq.) in dry DMF (2 ml_). The solution was cooled down to 0C and potassium carbonate (59.1 mg, 425 muiotatauiotaomicronIota, 1 .4 eq.) and 2-(difluoro- methyl)-1 /-/-benzoimidazole (69.5 mg, 414 muiotatauiotaomicronIota, 1.4 eq.) were added. The reaction mixture was stirred for 30 min at 0C and then for 2 h at RT. The solvent was removed under high vacuum and the remaining residue was purified directly by flash column chromatography (1 % MeOH/DCM) to yield the title compound as a white solid (53.7 mg, 48%). RF: 0.48 (DCM/MeOH, 95:5 v/v); 1H NMR (CDCI3, 400 MHz): delta 8.48 (d, J = 7.6 Hz, 1 H), 7.90 (d, J = 7.2 Hz, 1 H), 7.64 (t, J = 53.6 Hz, 1 H), 7.46-7.44 (m, 2H), 4.90 (s, 4H),4.49 (d, J = 9.6 Hz, 4H).
According to the analysis of related databases, 705-09-9, the application of this compound in the production field has become more and more popular.
Reference:
Patent; UNIVERSITY OF BASEL; CMILJANOVIC, Vladimir; CMILJANOVIC, Natasa; GIESE, Bernd; WYMANN, Matthias; WO2011/114275; (2011); A1;,
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