Electric Literature of 2620-76-0, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 2620-76-0 as follows.
A four-neck, 500 mL round bottom flask equipped with a top stirrer, nitrogen inlet, 125 mL addition funnel, and thermocouple was rinsed with dry nitrogen for 10 minutes. The flask was charged with 2-(4-bromophenyl)-1-phenyl-1H-benzo[d]imidazole (25.0 g, 71.59 mmol) and THF (250 mL), and the reaction was cooled to an internal temperature of -71V. 1.6 ME butyllithium (67 mL, 107.2 mmol) in hexane was added dropwise via an addition funnel over 30 minutes, and an additional 30 min was stirred at -72 °C. Add 2-isopropoxy-4,4,5,5-tetramethyl-1,3,2-di|1B boron boron by adding funnel (out 0 parent 31301>013116) (32 1111 ^, 171.99 mmol) to a deep red solution for 30 minutes, keeping the temperature below -70t. Remove the cold bath and allow the yellow slurry to warm to room temperature and mix for 16 h. The reaction was concentrated by rotary evaporation, then dissolved in dichloromethane (350 mL) and washed with water (200 mL) to form a cloudy mixture. The aqueous layer was extracted with dichloromethane (2 chi 150 mL) and the combined organic layers dried over EtOAc EtOAc EtOAc The resulting yellow solid was washed with hexanes (100 mL) which removed most of the color to afford 22.2 g of light brown solid. The solid was separated into two portions and recrystallized from EtOAc (EtOAc: EtOAc: EtOAc: EtOAc:
According to the analysis of related databases, 2620-76-0, the application of this compound in the production field has become more and more popular.
Reference:
Patent; DOW GLOBAL TECHNOLOGIES LLC; ROHM AND HAAS ELECTRONIC MATERIALS KOREA LTD.; WELSH, DEAN M.; ONDARI, MARK E.; GRAY, KAITLYN; KIM, BONG-OK; CHEE, MOO-KEUN; FROESE, ROBERT D.; (60 pag.)TWI631109; (2018); B;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem