Reference of 705-09-9, These common heterocyclic compound, 705-09-9, name is 2-(Difluoromethyl)-1H-benzo[d]imidazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: 2-(Difluoromethyl)-1H-benzo[d]imidazole (1 mol),chloro derivative (1 mol) and K2CO3 (2 mol) were taken inDMSO (10 v). The reaction mixture was heated to 130 C,stirred for 4 h. Then the reaction mixture was cooled to roomtemperature, diluted with water (50 v) extracted with EtOAC(2 x 50 v), evaporated the solvent under reduced pressure toget the crude compound. Crude products were purified bycolumn chromatography.
Statistics shows that 2-(Difluoromethyl)-1H-benzo[d]imidazole is playing an increasingly important role. we look forward to future research findings about 705-09-9.
Reference:
Article; Kasturi, Sivaprasad; Surarapu, Sujatha; Uppalanchi, Srinivas; Anantaraju, Hasitha Shilpa; Dwivedi, Shubham; Yogeeswari, Perumal; Ethiraj, Krishna S.; Anireddy, Jaya Shree; Letters in drug design and discovery; vol. 15; 2; (2018); p. 181 – 192;,
Imidazole – Wikipedia,
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