Some common heterocyclic compound, 705-09-9, name is 2-(Difluoromethyl)-1H-benzo[d]imidazole, molecular formula is C8H6F2N2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Product Details of 705-09-9
4-(4,6-Dichloro-1,3,5-triazin-2-yl)morpholine was added to a 500 mL single-mouth bottle (2)11.33g (48.2mmol), anhydrous potassium carbonate 6.66g (48.2mmol), DMF 150mL2-Difluoromethyl-1H-benzimidazole (3) 8.10 g (48.2 mmol) was added with stirring.2 hours at room temperature, add 200 mL of water, let stand, precipitate solids, filter under reduced pressure, with a small amountIt was washed with water and dried to give a white powdery solid 15.21 g The crude product yield was 86.03%.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 705-09-9, its application will become more common.
Reference:
Patent; Shenyang Pharmaceutical University; Sun Tiemin; Zhou Zhixu; Du Lei; Yan Ning; Wang Yude; Li Linwei; (14 pag.)CN105130960; (2018); B;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem