Synthetic Route of 39070-14-9,Some common heterocyclic compound, 39070-14-9, name is (1-Methyl-2-nitro-1H-imidazol-5-yl)methanol, molecular formula is C5H7N3O3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To a solution of Compound i (1 g) in DMF (15 mL) was added N- bromosuccinimide (NBS, 1.25 g) and the reaction mixture stirred at 600C for 3h. Then the reaction mixture was diluted with brine, extracted with EtOAc, dried and concentrated to yield a residue that was separated by column chromatography using 0 – 80% EtOAc/Hexanes to yield Compound ii (1.3 g).
The synthetic route of 39070-14-9 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; THRESHOLD PHARMACEUTICALS, INC.; CHEN, Tao; WO2008/151253; (2008); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem