Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 17325-26-7, name is Methyl 1H-imidazole-5-carboxylate, A new synthetic method of this compound is introduced below., Formula: C5H6N2O2
General procedure: Method B: Compounds 22 or 23 (1.2 mmol) and cesium carbonate (390 mg, 1.2 mmol) were dissolved in dry DMF (3 mL) under argon. After stirring of the mixture for 30 min at 50 C, a solution of the tosyl ester 12c or 12d (1 mmol) dissolved in dry DMF (3 mL) was added and the stirring was continued overnight at 50 C under argon. After evaporation of DMF in high vacuo, the residue was dissolved in EtOAc and the organic phase was washed with brine to neutral pH, dried over Na2SO4 and evaporated under reduced pressure. The residual product was purified by column chromatography (silica gel) using the appropriate solvent systems as it will be defined, in each case, below.
The synthetic route of 17325-26-7 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Moutevelis-Minakakis, Panagiota; Papavassilopoulou, Eleni; Michas, George; Georgikopoulou, Kalliopi; Ragoussi, Maria-Eleni; Neophytou, Niki; Zoumpoulakis, Panagiotis; Mavromoustakos, Thomas; Hadjipavlou-Litina, Dimitra; Bioorganic and Medicinal Chemistry; vol. 19; 9; (2011); p. 2888 – 2902;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem