Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 68282-53-1, name is 5-Methyl-1H-imidazole-4-carbaldehyde, This compound has unique chemical properties. The synthetic route is as follows., name: 5-Methyl-1H-imidazole-4-carbaldehyde
To a solution of 1-(5-chloropyridin-2-yl)-1-(3-fluoro-5-(trifluoromethyl)phenyl)-2-phenylethanamine (0.02 g, 0.051 mmol) in dichloroethane (0.5 mL) in a two dram vial was added 4-methyl-1H-imidazole-5-carbaldehyde (6 mg, 0.051 mmol), followed by a drop of acetic acid. The reaction mixture was shaken for 20 minutes at room temperature and then NaBH(OAc)3 was added (12 mg, 0.056 mmol). The reaction was stirred at room temperature overnight. The solvents were removed and the residue was purified by preparative HPLC (phenominex C18 column, 21×100 mm, 5 mu) using MeOH/H2O (with 0.1% TFA) to give 1-(5-chloropyridin-2-yl)-1-(3-fluoro-5-(trifluoromethyl)phenyl)-N-((4-methyl-1H-imidazol-5-yl)methyl)-2-phenylethanamine as a white solid (23.4 mg, 76% yield). LCMS: 3.6 min [M+1] 489.2 (4 min gradient, MeOH/H2O 0.1% TFA); 1H NMR (400 MHz, CDCl3) delta ppm 2.27 (s, 3H), 3.45-3.52 (m, 1H), 3.88-3.99 (m, 2H), 4.01-4.07 (m, 1H), 6.64 (d, J=7.09 Hz, 2H), 7.02 (d, J=8.56 Hz, 1H), 7.10 (t, J=7.46 Hz, 2H), 7.18 (t, J=7.46 Hz, 1H), 7.49 (d, J=7.58 Hz, 1H), 7.61 (d, J=9.54 Hz, 1H), 7.69 (s, 1H), 7.76 (dd, J=8.56, 2.45 Hz, 1H), 8.28 (s, 1H), 8.60 (d, J=1.96 Hz, 1H).
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 68282-53-1.
Reference:
Patent; Bristol-Myers Squibb Company; US2007/161685; (2007); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem