Electric Literature of 118469-15-1, The chemical industry reduces the impact on the environment during synthesis 118469-15-1, name is 5-Fluoro-2-methyl-1H-benzo[d]imidazole, I believe this compound will play a more active role in future production and life.
In a 150 mL round bottom flask, intermediate VI-13 2-methyl 5-fluorobenzimidazole (0.31 g, 2.04 mmol) was added, and potassium carbonate was used as a base (0.30 g, 2.20 mmol), and acetonitrile was stirred at 50 C as a solvent. After 40 minutes, after cooling to room temperature, intermediate V (0.43 g, 1.70 mmol) was added and the mixture was warmed to 75 C. After concentration, extraction, column chromatography separation, drying, etc., the intermediate X-13 (0.48 g) is obtained in a yield of 77.8%; white solid
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 5-Fluoro-2-methyl-1H-benzo[d]imidazole, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Southwest University; Zhou Chenghe; Man Nabaonei·lamohan·laao·yadafu; Wang Juan; (39 pag.)CN110305064; (2019); A;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem