Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 17325-26-7, name is Methyl 1H-imidazole-5-carboxylate, This compound has unique chemical properties. The synthetic route is as follows., COA of Formula: C5H6N2O2
0.76 g of imidazole-4-carboxylic acid methyl ester (6 mmol) was dissolved in 10 ml of acetone solution.0.66 ml (6.6 mmol) of 1,3-dibromopropane was added in that order.K2CO31.66g (12mmol),Bu4N+Br-0.12g (0.36mmol),Heated at 51 C for 7.5 h.TLC monitoring showed completion of the reaction. The reaction solution is dried,Dilute with 25 ml of ethyl acetate.Washed 5-6 times, the organic phase was washed with saturated sodium chloride (20 ml).Dry over anhydrous sodium sulfate, suction filtration, spin dry, flash column chromatography (PE/EA = 1:1),Methyl 1-(3-bromopropyl)imidazole-4-carboxylate (light yellow solid)0.57 mg, yield 38.9%.
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 17325-26-7.
Reference:
Patent; China Pharmaceutical University; Chen Li; Xu Manyi; Li Na; Pei Jianghong; Bao Na; Shi Wei; (31 pag.)CN109336944; (2019); A;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem