89830-98-8, name is 5-Cyclopropyl-1H-imidazole, belongs to imidazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Product Details of 89830-98-8
To a flask were added 2-chloro-5-fluoro-4-iodopyridine (23.0 g, 89.3 mmol), 4-cyclopropyl-1H-imidazole (29.0 g, 268 mmol), potassium carbonate (30.8 g, 223 mmol), cuprous iodide (340 mg, 1.79 mmol), 8-hydroxyquinaldine (569 mg, 3.57 mmol) and dimethylsulfoxide (80 mL) under nitrogen. The mixture was heated to 90 C and stirred overnight. The resulting mixture was cooled to rt naturally and quenched with water (100 mL) and then extracted with EtOAc (200 mL x 2). The combined organic layers were washed with saturated brine (100 mL), dried over anhydrous Na2SO4. The mixture was filtered and the filtrate was concentrated in vacuo. The residue was purified by silica-gel column chromatography (DCMIEtOAc (V/V) = 10/1-5/1) to give the title compound as a yellow solid (4.50 g, 2 1%).?HNIVIR(400MH4 CDCl3)8.40(d,J=2.7H4 1H), 7.92 (s, 1H), 7.38 (d,J= 5.4 H4 1H), 7.11 (s, 1H), 1.96-1.82 (m, 1H), 0.96 – 0.87 (m, 2H), 0.86- 0.80 (m, 2H?).
The synthetic route of 89830-98-8 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; SUNSHINE LAKE PHARMA CO., LTD.; YANG, Xinye; PAN, Shengqiang; MA, Facheng; ZHANG, Yingxun; WANG, Xiaojun; ZHANG, Yingjun; JIN, Chuanfei; ZHANG, Ji; (105 pag.)WO2019/34096; (2019); A1;,
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