Related Products of 6775-40-2,Some common heterocyclic compound, 6775-40-2, name is 5-Phenyl-1H-imidazol-2-amine, molecular formula is C9H9N3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
dissolving 2-amino-4-phenyl-1H-imidazole and iodobenzene in anhydrous t-butanol,Reaction at 80 C for 16h under the action of a catalytic system, cooled to 50 C,The reaction solvent was drained under vacuum, and extracted with dichloromethane several times, and centrifuged.A green dichloromethane extract is obtained. After the extraction is complete, the extract is collected.And dried under vacuum to obtain a crude product, which was recrystallized from a toluene / n-hexane mixed solution,Light green crystal product1,4-diphenyl-1H-imidazol-2-amine,Yield 61%,
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 5-Phenyl-1H-imidazol-2-amine, its application will become more common.
Reference:
Patent; Donghua University; Cai Zhengguo; Li Yanqing; Xiao Ru; (35 pag.)CN110396116; (2019); A;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem