6160-65-2, name is 1,1′-Thiocarbonyldiimidazole, belongs to imidazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. SDS of cas: 6160-65-2
INTERMEDIATE 45Methyl 3-(f(35r)-4-(aminocarbonothioyl)mophiholin-3-yllmethyl|-l-methyl-lH-indole-5- carboxylateTo a stirred slurry of Intermediate 44 (31.64 g, 109.7 mmol) in TetaF (221 mL) at r.t. was added l,r-thiocarbonyldiimidazole (21.51 g, 120.7 mmol) portionwise over 10 minutes. The reaction mixture was stirred at r.t. for 5 h, then transferred to a pressure vessel and NH3 (111 mL of a 28% aqueous solution, 1.6 mol) was added. This mixture was stirred at 600C for 17 h, then cooled to r.t. It was diluted with water (158 mL) and solid product was filtered off, washed with water and dried in vacuo at 450C, to give the title compound (37.79 g, 99.1%) as a white solid. LCMS (ES+) 348.0 (M+H)+, RT 2.88 minutes (Method I).
The synthetic route of 6160-65-2 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; UCB PHARMA S.A.; WO2009/71895; (2009); A1;,
Imidazole – Wikipedia,
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