85692-37-1, name is 1-(1-Methyl-1H-imidazol-2-yl)ethanone, belongs to imidazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Recommanded Product: 1-(1-Methyl-1H-imidazol-2-yl)ethanone
A mixture of N-(4-ethynylphenyl)-2-(4-formylphenyl)acetamide (184 mg, 0.7 mmol), N-methyl imidazole ketone 2b (99 mg, 0.8 mmol, 1.2 equivalents), piperidine (0.2 ml, 2.1 mmol, 3 equivalents) and anhydrous methanol (5 ml) placed in a 10 mL microwave vial was heated in a microwave synthesizer at 85 C for 6 hours. The crude reaction mixture was concentrated and purified by flash chromatography on silica gel in ethyl acetate/ hexanes (20 %-> 70% ethyl acetate) to obtain 41 (59 mg, 23%). NMR (600 MHz, CDC13) delta 8.09 (d, J = 15.9 Hz, 1H), 7.80 (d, J = 16.0 Hz, 1H), 7.70 (t, J = 6.9 Hz, 2H), 7.39 (s, 4H), 7.35 (d, J = 8.0 Hz, 2H), 7.22 (s, 1H), 7.11 (s, 1H), 7.08 (s, 1H), 4.09 (s, 3H), 3.74 (s, 2H), 3.01 (s, 1H).HRMS calculated 370.1556 found 370.1563 [M+H]+ ion.
The synthetic route of 85692-37-1 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; THE UNIVERSITY OF TOLEDO; TILLEKERATNE, Viranga; AL-HAMASHI, Ayad; DLAMINI, Samkeliso; ALQAHTANI, Abdulateef, Saeed; KARAJ, Endri; (69 pag.)WO2019/36607; (2019); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem