Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 14741-71-0, name is Ethyl 2-(1H-benzo[d]imidazol-2-yl)acetate, A new synthetic method of this compound is introduced below., Recommanded Product: Ethyl 2-(1H-benzo[d]imidazol-2-yl)acetate
To a solution of compound 3 (2.04 g, 0.01 mol) in ethanol (40 mL) hydrazine hydrate (0.50 g,0.01 mol) was added. The reaction mixture was heated under reflux for 6 h then poured ontoice/water mixture containing few drops of hydrochloric acid and the formed solid product wascollected by filtration. Brown crystals from ethanol; yield: 1.15 g (80%); m.p. > 300 oC. IR, :3488-3429 (NH2, NH), 3054 (CH aromatic), 2983 (CH2), 1684 (CO), 1640 (C=N), 1630 (C=C).1H-NMR: : 4.93 (s, 2H, CH2), 4.89 (s, 2H, NH2, D2O exchangeable), 7.29-7.39 (m, 4H, C6H4),8.28, 8.32 (2s, 2H, 2NH, D2O exchangeable). 13C NMR (DMSO): 52.8 (CH2), 120.3, 123.8,124.6, 126.4, 127.3, 129.8 (C6H4), 163.8 (CO), 173.4 (C=N); Anal. calcd for C9H10N4O: C,56.83; H, 5.30; N, 29.46%. Found: C, 56.66; H, 5.28; N, 29.69%. MS: m/z: (%) 190 (M+, 36%).
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Article; Mohareb, Rafat M.; Gamaan, Marwa S.; Bulletin of the Chemical Society of Ethiopia; vol. 32; 3; (2018); p. 541 – 557;,
Imidazole – Wikipedia,
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