In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 705-09-9, name is 2-(Difluoromethyl)-1H-benzo[d]imidazole belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below. category: imidazoles-derivatives
Step 1: 4-(6-bromo-2-(2-(difIuoromethyl)-lH-benzo[d]imidazol-l-yl)-8-methoxyquinazoHn-4-yl)morpholineTo a stirred mixture of 4-(6-bromo-2-chloro-8-methoxyquinazolin-4-yl)morpholine (300 mg, 0.00084 mol) and potassium carbonate (348 mg, 0.00251 mol) in N,N-dimethylformamide ( 10 ml) was added 2-(difluoromethyl)-lH-benzo[d] imidazole (169 mg, 0.001 mol) at room temperature. The reaction mixture was heated at 80C for 16 h. The reaction mixture was added to ice-cold water ( 100 mL). The solid separated was collected by filtration, washed with 5% EtOAc in hexane and dried under vacuum to afford the title compound as white solid (230 mg, 56%). H NMR (400 MHz, DMSO-d6) : delta 8.67 (d, J = 8.40 Hz, 1 H), 7.96 (t, J = 53.2 Hz, 1H), 7.87 (d, J = 8.0 Hz, 1H), 7.73 (d, J = 2.0 Hz, 1H), 7.54 (d, J = 2.0 Hz, 1H), 7.53-7.43 (m, 2H), 4.05 (s, 3H), 3.94-3.83 (m, 8H); ESI-MS : Calculated mass: 489.06; Observed mass: 490.20 [M + H]+.
The synthetic route of 705-09-9 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; ASANA BIOSCIENCES, LLC; THOMPSON, Scott, K.; SMITH, Roger, A.; REDDY, Sanjeeva; JOHN, Tyler, M.; NYAVANANDI, Vijay, Kumar; SUBRAMANYA, Hosahalli; POTLURI, Vijay; PANIGRAHI, Sunil, Kumar; NADIPALLI, Prabhakara, Rao; SENGUPTA, Saumitra; WO2014/169167; (2014); A1;,
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