Addla, Dinesh; Jallapally, Anvesh; Kanwal, Abhinav; Sridhar, Balasubramanian; Banerjee, Sanjay K.; Kantevari, Srinivas published the article 《Design, synthesis and evaluation of novel 2-hydroxypyrrolobenzodiazepine-5,11-dione analogues as potent angiotensin converting enzyme (ACE) inhibitors》. Keywords: angiotensin converting enzyme ACE inhibitor preparation; crystal structure.They researched the compound: 4-(Bromomethyl)-1-chloro-2-fluorobenzene( cas:206362-80-3 ).Electric Literature of C7H5BrClF. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:206362-80-3) here.
A series of novel 10-substituted 2-hydroxypyrrolobenzodiazepine-5,11-diones I [R = Me, MeC(O), Ph, etc.] designed through structure based rational hybridization approach, synthesized by the cyclodehydration of isotonic anhydride with (2S,4R)-4-hydroxypyrrolidine-2-carboxylic acid followed by N-substitution, were evaluated as angiotensin converting enzyme (ACE) inhibitors. Among all the new compounds screened (2R,11aS)-10-((4-bromothiophen-2-yl)methyl)-2-hydroxy-2,3-dihydro-1H-benzo[e]pyrrolo[1,2-a][1,4]diazepine-5,11(10H,11aH)dione, I [R = 3,4,5-(MeO)3C6H2] (IC50: 0.272 μM) emerged as most active noncarboxylic acid ACE inhibitor with minimal toxicity comparable to clin. drugs Lisinopril, Benazepril and Ramipril. Favorable binding characteristics in docking studies also supported the exptl. results.
If you want to learn more about this compound(4-(Bromomethyl)-1-chloro-2-fluorobenzene)Electric Literature of C7H5BrClF, you may wish to communicate with the author of the article,or consult the relevant literature related to this compound(206362-80-3).
Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem