In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Facile synthesis of silver-rich Au/Ag bimetallic nanoparticles with highly active SERS properties, published in 2019, which mentions a compound: 16961-25-4, mainly applied to protein anaylsis immunoassay silver gold bimetallic nanoparticle SERS, Quality Control of Hydrogen tetrachloroaurate(III) trihydrate.
The sensitive detection of proteins has attracted great interest in biomedical research since abnormal concentrations of certain proteins often indicate the presence of various chronic diseases. In this work, we propose an immunoassay method based on surface-enhanced Raman scattering (SERS) for the proof-of-concept determination of proteins by using Atto-610 labeled Au/Ag bimetallic nanoparticles (BNPs) as nanotags and a Au/Ag bimetallic film as a substrate. Without the need for added surfactants or organic precursors during the preparation process, silver-enriched Au/Ag BNPs are obtained with relatively clean surfaces by combining a galvanic replacement (GR) reaction with co-reduction of Ag atoms. The changes in morphol., composition and surface plasmon resonance (SPR) involved in the GR reaction are systematically characterized, and the possible mechanism is discussed. The BNPs exhibit considerable SERS activity due to the enrichment of Ag in the nanostructures. Upon the introduction of AuNPs by gold staining, a SERS-based super-sandwich structure is generated that is suitable for immunoassays. Using this approach, rabbit IgG is detected over a wide concentration range with a detection limit of 10 pg L-1.
This literature about this compound(16961-25-4)Quality Control of Hydrogen tetrachloroaurate(III) trihydratehas given us a lot of inspiration, and I hope that the research on this compound(Hydrogen tetrachloroaurate(III) trihydrate) can be further advanced. Maybe we can get more compounds in a similar way.
Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem