In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Palladium-Catalyzed Divergent Cyclopropanation by Regioselective Solvent-Driven C(sp3)-H Bond Activation, published in 2018, which mentions a compound: 58656-04-5, mainly applied to spiro fused cyclopropanated indoline preparation cyclopropanation regioselective palladium catalyst; C−H activation; heterocylces; palladium; reaction mechanisms; solvent effects, Application In Synthesis of Tricyclohexylphosphonium tetrafluoroborate.
Reported is a tandem palladium-catalyzed Heck/regioselective C(sp3)-H activation reaction for the divergent synthesis of spiro- and fused-cyclopropanated indolines from N-methallylated 2-bromoarylamides. The regioselectivity of the C-H bond activation in the σ-alkyl PdII intermediate is controlled by the solvent used. DFT calculations suggest that the polarity of solvent mols. could influence the transition-state energy, leading to a bifurcation of the C-H bond activation in the σ-alkyl PdII intermediate.
Compound(58656-04-5)Application In Synthesis of Tricyclohexylphosphonium tetrafluoroborate received a lot of attention, and I have introduced some compounds in other articles, similar to this compound(Tricyclohexylphosphonium tetrafluoroborate), if you are interested, you can check out my other related articles.
Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem