The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 3-Pyridinepropionic acid(SMILESS: OC(=O)CCC1=CC=CN=C1,cas:3724-19-4) is researched.HPLC of Formula: 86404-63-9. The article 《Discovery of Potent Hexapeptide Agonists to Human Neuromedin U Receptor 1 and Identification of Their Serum Metabolites》 in relation to this compound, is published in ACS Medicinal Chemistry Letters. Let’s take a look at the latest research on this compound (cas:3724-19-4).
Neuromedin U (NMU) and S (NMS) display various physiol. activities, including an anorexigenic effect, and share a common C-terminal heptapeptide-amide sequence that is necessary to activate two NMU receptors (NMUR1 and NMUR2). On the basis of this knowledge, the authors recently developed hexapeptide agonists, which are highly selective to human NMUR1 and NMUR2, resp. However, the agonists are still less potent than the endogenous ligand, hNMU. Therefore, the authors performed an addnl. structure-activity relationship study, which led to the identification of a more potent hexapeptide I that exhibits similar NMUR1-agonistic activity as compared to hNMU. Addnl., the authors studied the stability of synthesized agonists, including I, in rat serum, and identified two major biodegradation sites: Phe2-Arg3 and Arg5-Asn6. The latter was more predominantly cleaved than the former. Moreover, substitution with 4-fluorophenylalanine, as in I, enhanced the metabolic stability at Phe2-Arg3. These results provide important information to guide the development of practical hNMU agonists.
Compound(3724-19-4)Application In Synthesis of 3-Pyridinepropionic acid received a lot of attention, and I have introduced some compounds in other articles, similar to this compound(3-Pyridinepropionic acid), if you are interested, you can check out my other related articles.
Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem