Safety of Pentaerythrityltetrabromide. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: Pentaerythrityltetrabromide, is researched, Molecular C5H8Br4, CAS is 3229-00-3, about Spirans. X. 2,2′,3,3′-Tetrahydro-3,3′-spirobis[4H-[1,5]benzooxathiepin] and 2,3,4,5-tetrahydrospiro[1H-benzo[f][1,5]diazepine-3,1′-cyclopropane]. Rapid equilibrium between diastereoisomeric forms. Author is Smolinski, S.; Kubaszek, M.; Nagraba, K..
NMR showed that the 2 heterocyclic rings of the spiran I, prepared in 2% yield from o-HSC6H4OH di-Na salt and C(CH2Br)4, were in the chair form. I was represented by 3 topologically equivalent diastereoisomeric structures. Two structures possessed C2-sym. and one C1-sym. o-(H2N)2C6H4 and C(CH2Br)4 in the presence of Cu-bronze gave 1.3% spiran II whose heterocyclic ring was in the chair form.
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Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem