The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 3-Pyridinepropionic acid( cas:3724-19-4 ) is researched.Electric Literature of C8H9NO2.Lu, Shui-Yu; Chin, Frederick T.; McCarron, Julie A.; Pike, Victor W. published the article 《Efficient O- and N-(β-fluoroethylation)s with NCA [18F]β-fluoroethyl tosylate under microwave-enhanced conditions》 about this compound( cas:3724-19-4 ) in Journal of Labelled Compounds & Radiopharmaceuticals. Keywords: fluorine 18 beta microwave fluoroethylation amine phenol carboxylic acid; pipecolinic acid chemoselective fluorine 18 beta microwave fluoroethylation. Let’s learn more about this compound (cas:3724-19-4).
Reactions of no-carrier-added (NCA) [18F]β-fluoroethyl tosylate with amine, phenol or carboxylic acid in the presence of base (e.g. Cs2CO3) to form the corresponding [18F]N-(β-fluoroethyl)amine, [18F]β-fluoroethyl ether or [18F]β-fluoroethyl ester, are rapid (2-10 min) and efficient (51-89% conversion) under microwave-enhanced conditions. These conditions allow reactants to be heated rapidly to 150° in a low b.p. solvent, such as MeCN, and avoid the need to use high b.p. solvents, such as DMSO and DMF, to promote reaction. The microwave-enhanced reactions gave ∼20% greater radiochem. yields than thermal reactions performed at similar temperatures and over similar reaction times. With a bi-functional mol., such as DL-pipecolinic acid, [18F]β-fluoroethyl tosylate reacts exclusively with the amino group.
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Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem