Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: Tricyclohexylphosphonium tetrafluoroborate, is researched, Molecular C18H34BF4P, CAS is 58656-04-5, about Palladium-Catalyzed Suzuki-Miyaura Cross-Coupling of Amides via Site-Selective N-C Bond Cleavage by Cooperative Catalysis.Category: imidazoles-derivatives.
Palladium-catalyzed Suzuki-Miyaura cross-coupling of primary benzamides enabled by a merger of site-selective N,N-di-Boc-activation and cooperative catalysis via N-C bond cleavage for the synthesis of biaryl ketones is reported. We present the synergistic combination of Lewis base and palladium catalysis as a concept to activate inert amide N-C bonds. The mild reaction conditions provide a direct route to structurally diverse ketones. The reaction tolerates a wide range of electrophilic functional groups. Considering the fundamental importance of primary amides as pharmaceutical and synthetic intermediates, the strategy has a potential for developing a diverse array of valuable amide N-C bond functionalization reactions by the synergistic merger of Lewis base and organometallic catalysis.
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Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem