The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: Hydrogen tetrachloroaurate(III) trihydrate, is researched, Molecular AuCl4H7O3, CAS is 16961-25-4, about Targeting pancreatic cancer cells and stellate cells using designer nanotherapeutics in vitro, the main research direction is cetuximab gemcitabine gold nanoparticle pancreatic cancer stellate cell nanotherapeutics; PEGylation; drug delivery; gold nanoparticles; pancreatic cancer.Recommanded Product: 16961-25-4.
Pancreatic cancer (PC) is characterized by a robust desmoplastic environment, which limits the uptake of the standard first-line chemotherapeutic drug gemcitabine. Enhancing gemcitabine delivery to the complex tumor microenvironment (TME) is a major clin. challenge. Mol. crosstalk between pancreatic cancer cells (PCCs) and pancreatic stellate cells (PSCs) plays a critical role in desmoplastic reaction in PCs. Herein, we report the development of a targeted drug delivery system to inhibit the proliferation of PCCs and PSCs in vitro. Using gold nanoparticles as the delivery vehicle, the anti-EGFR antibody cetuximab (C225/C) as a targeting agent, gemcitabine as drug and polyethylene glycol (PEG) as a stealth mol., we created a series of targeted drug delivery systems. Fabricated nanoconjugates were characterized by various physicochem. techniques such as UV-Visible spectroscopy, transmission electron microscopy, HPLC and instrumental neutron activation anal. (INAA). Targeted gemcitabine delivery systems containing mPEG-SH having mol. weights of 550 Da or 1000 Da demonstrated superior efficacy in reducing the viability of both PCCs and PSCs as compared to their non-targeted counterparts. EGFR-targeted pathway was further validated by pre-treating cells with C225 followed by determining cellular viability. Taken together, in our current study we have developed a PEGylated targeted nanoconjugate ACG44P1000 that showed enhanced selectivity towards pancreatic cancer cells and pancreatic stellate cells, among others, for gemcitabine delivery. We will investigate the ability of these optimized conjugates to inhibit desmoplasia and tumor growth in vivo in our future studies.
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Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem