Formula: AuCl4H7O3. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: Hydrogen tetrachloroaurate(III) trihydrate, is researched, Molecular AuCl4H7O3, CAS is 16961-25-4, about Doxorubicin-loaded gold nanorods: a multifunctional chemo-photothermal nanoplatform for cancer management. Author is Awan, Uzma Azeem; Raza, Abida; Ali, Shaukat; Saeed, Rida Fatima; Akhtar, Nosheen.
Two of the limitations associated with cancer treatment are the low efficacy and the high dose-related side effects of anticancer drugs. The purpose of the current study was to fabricate biocompatible multifunctional drug-loaded nanoscale moieties for co-therapy (chemo-photothermal therapy) with maximum efficacy and min. side effects. Herein, we report in vitro anticancerous effects of doxorubicin (DOX) loaded on gold nanorods coated with the polyelectrolyte poly(sodium-4-styrenesulfonate) (PSS-GNRs) with and without NIR laser (808 nm, power d. = 1.5 W/cm2 for 2 min) irradiation The drug-loading capacity of PSS-GNRs was about 76% with a drug loading content of 3.2 mg DOX/mL. The cumulative DOX release significantly increased after laser exposure compared to non-irradiated samples (p < 0.05). The zeta potential values of GNRs, PSS-GNRs and DOX-PSS-GNRs were measured as 42 ± 0.1 mV, -40 ± 0.3 mV and 39.3 ± 0.6 mV, resp. PSS-GNRs nanocomplexes were found to be biocompatible and showed higher photothermal stability. The DOX-conjugated nanocomplexes with NIR laser irradiation appear more efficient in cell inhibition (93%) than those without laser exposure (65%) and doxorubicin alone (84%). The IC50 values of PSS-GNRs-DOX and PSS-GNRs-DOX were measured as 7.99 and 3.12μg/mL, resp., with laser irradiation Thus, a combinatorial approach based on chemotherapy and photothermal strategies appears to be a promising platform in cancer management. I hope my short article helps more people learn about this compound(Hydrogen tetrachloroaurate(III) trihydrate)Formula: AuCl4H7O3. Apart from the compound(16961-25-4), you can read my other articles to know other related compounds.
Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem