Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 16961-25-4, is researched, SMILESS is Cl[Au-](Cl)(Cl)Cl.[H]O[H].[H]O[H].[H]O[H].[H+], Molecular AuCl4H7O3Journal, Article, Research Support, Non-U.S. Gov’t, Scientific Reports called Antimicrobial activities of green synthesized gums-stabilized nanoparticles loaded with flavonoids, Author is Anwar, Ayaz; Masri, Abdulkader; Rao, Komal; Rajendran, Kavitha; Khan, Naveed Ahmed; Shah, Muhammad Raza; Siddiqui, Ruqaiyyah, the main research direction is gum stabilized nanoparticle flavonoid green synthesis antimicrobial activity.HPLC of Formula: 16961-25-4.
Herein, we report green synthesized nanoparticles based on stabilization by plant gums, loaded with citrus fruits flavonoids Hesperidin (HDN) and Naringin (NRG) as novel antimicrobial agents against brain-eating amoebae and multi-drug resistant bacteria. Nanoparticles were thoroughly characterized by using zetasizer, zeta potential, at. force microscopy, ultravoilet-visible and Fourier transform-IR spectroscopic techniques. The size of these spherical nanoparticles was found to be in the range of 100-225 nm. The antiamoebic effects of these green synthesized Silver and Gold nanoparticles loaded with HDN and NRG were tested against Acanthamoeba castellanii and Naegleria fowleri, while antibacterial effects were evaluated against methicillin-resistant Staphylococcus aureus (MRSA) and neuropathogenic Escherichia coli K1. Amoebicidal assays revealed that HDN loaded Silver nanoparticles stabilized by gum acacia (GA-AgNPs-HDN) quant. abolished amoeba viability by 100%, while NRG loaded Gold nanoparticles stabilized by gum tragacanth (GT-AuNPs-NRG) significantly reduced the viability of A. castellanii and N. fowleri at 50μg per mL. Furthermore, these nanoparticles inhibited the encystation and excystation by more than 85%, as well as GA-AgNPs-HDN only completely obliterated amoeba-mediated host cells cytopathogenicity. Whereas, GA-AgNPs-HDN exhibited significant bactericidal effects against MRSA and E. coli K1 and reduced bacterial-mediated host cells cytotoxicity. Notably, when tested against human cells, these nanoparticles showed minimal (23%) cytotoxicity at even higher concentration of 100μg per mL as compared to 50μg per mL used for antimicrobial assays. Hence, these novel nanoparticles formulations hold potential as therapeutic agents against infections caused by brain-eating amoebae, as well as multi-drug resistant bacteria, and recommend a step forward in drug development.
I hope my short article helps more people learn about this compound(Hydrogen tetrachloroaurate(III) trihydrate)HPLC of Formula: 16961-25-4. Apart from the compound(16961-25-4), you can read my other articles to know other related compounds.
Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem