Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 206362-80-3, is researched, SMILESS is ClC1=C(C=C(CBr)C=C1)F, Molecular C7H5BrClFJournal, Article, Research Support, Non-U.S. Gov’t, Organic & Biomolecular Chemistry called Rhodium(III)-catalyzed regioselective C2-amidation of indoles with N-(2,4,6-trichlorobenzoyloxy)amides and its synthetic application to the development of a novel potential PPARγ modulator, Author is Shi, Jingjing; Zhao, Guanguan; Wang, Xiaowei; Xu, H. Eric; Yi, Wei, the main research direction is rhodium catalyst regioselective amidation indole trichlorobenzoyloxyamide; PPARgamma agonist indole trichlorobenzoyloxyamide.Name: 4-(Bromomethyl)-1-chloro-2-fluorobenzene.
A new and efficient method for the direct regioselective C2-amidation of various functionalized indoles with several N-(2,4,6-trichlorobenzoyloxy)amides via Rh(III)-catalyzed C-H activation/N-O cleavage/C-N formation using the pyrimidyl group as a readily installable and removable directing group has been developed. With this method, a variety of valuable 2-amido indoles can be easily prepared under mild conditions with broad functional group tolerance and excellent region-/site-specificities. The results from biol. evaluation showed that compound I had a partial PPARγ agonistic activity and a strong PPARγ binding affinity with an IC50 value of 120.0 nM, along with a less pronounced adipocyte differentiation ability compared to the currently marketed anti-diabetic drug rosiglitazone, suggesting that further development of such a compound might be of great interest.
In addition to the literature in the link below, there is a lot of literature about this compound(4-(Bromomethyl)-1-chloro-2-fluorobenzene)Name: 4-(Bromomethyl)-1-chloro-2-fluorobenzene, illustrating the importance and wide applicability of this compound(206362-80-3).
Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem