The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 3-Pyridinepropionic acid( cas:3724-19-4 ) is researched.Category: imidazoles-derivatives.Bay, Anna V.; Fitzpatrick, Keegan P.; Gonzalez-Montiel, Gisela A.; Farah, Abdikani Omar; Cheong, Paul Ha-Yeon; Scheidt, Karl A. published the article 《Light-Driven Carbene Catalysis for the Synthesis of Aliphatic and α-Amino Ketones》 about this compound( cas:3724-19-4 ) in Angewandte Chemie, International Edition. Keywords: aliphatic amino ketone preparation; acyl imidazole amino acid benzyl Hantzsch ester benzylation; carbene; catalysis; density functional theory; late-stage functionalization; photochemistry. Let’s learn more about this compound (cas:3724-19-4).
Single-electron N-heterocyclic carbene (NHC) catalysis has gained attention recently for the synthesis of C-C bonds. Guided by d. functional theory and mechanistic analyses, authors report the light-driven synthesis of aliphatic and α-amino ketones using single-electron NHC operators. Computational and exptl. results reveal that the reactivity of the key radical intermediate is substrate-dependent and can be modulated through steric and electronic parameters of the NHC. Catalyst potential is harnessed in the visible-light driven generation of an acyl azolium radical species that underwent selective coupling with various radical partners to afford diverse ketone products. This methodol. is showcased in the direct late-stage functionalization of amino acids and pharmaceutical compounds, highlighting the utility of single-electron NHC operators.
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Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem