Month: April 2022

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 16961-25-4, is researched, SMILESS is Cl[Au-](Cl)(Cl)Cl.[H]O[H].[H]O[H].[H]O[H].[H+], Molecular AuCl4H7O3Journal, Evaluation Study, Article, Journal of Agricultural and Food Chemistry called Competitive lateral flow immunoassay relying on Au-SiO2 Janus nanoparticles with an asymmetric structure and function for furazolidone residue monitoring, Author is Su, Lihong; Wang, Lulu; Xu, Jingke; Wang, Zonghan; Yao, Xiaolin; Sun, Jing; Wang, Jianlong; Zhang, Daohong, the main research direction is lateral flow immunoassay gold silica Janus nanoparticle furazolidone; food safety antibiotic residue lateral flow immunoassay; Au−SiO2 Janus nanoparticle; asymmetric structure; furazolidone; lateral flow immunoassay.Name: Hydrogen tetrachloroaurate(III) trihydrate.

Gold nanoparticles (AuNPs) are the most commonly used signal materials in lateral flow immunoassay (LFIA). However, the assay sensitivity of traditional AuNP-based LFIA is usually limited by the incomplete competition between free target analytes and immobilized antigens for the binding of AuNP-labeled antibodies. To unfreeze this limitation, here, asym. Au-SiO2 Janus NPs (about 66 nm) were designed and synthesized. Au-SiO2 Janus NPs can assemble into snowman-like anisotropic structures and combine two different physicochem. properties at their opposite sides, where the AuNP side mainly possesses the antibody conjugating and signal providing functions and the SiO2 side primarily offers the stable function. In virtue of the unique asym. nanostructure, only the AuNP side can interact with target analytes by specific antigen-antibody interactions, which could significantly improve the efficiency of competition. Selecting furazolidone as a model analyte, the immunoassay biosensor showed a limit of detection as low as 0.08 ng/mL, 10-fold decreased than that of the AuNPs-LFIA. Moreover, the Au-SiO2 Janus NP lateral flow immunoassay was well applied in chicken, pork, honey, and beef food samples with visual detection limits of 0.8 ng/g, 0.16 ng/g, 0.4 ng/mL, and 0.16 ng/g, resp. The Au-SiO2 Janus NPs possess the advantages of both materials, which will broaden their applications as a potential alternative in the rapid and sensitive detection of antibiotic residues.

Although many compounds look similar to this compound(16961-25-4)Name: Hydrogen tetrachloroaurate(III) trihydrate, numerous studies have shown that this compound(SMILES:Cl[Au-](Cl)(Cl)Cl.[H]O[H].[H]O[H].[H]O[H].[H+]), has unique advantages. If you want to know more about similar compounds, you can read my other articles.

Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Sangkheaw, Ponkarnan; Therdthianwong, Supaporn; Therdthianwong, Apichai; Wongyao, Nutthapon; Yongprapat, Sarayut published an article about the compound: Hydrogen tetrachloroaurate(III) trihydrate( cas:16961-25-4,SMILESS:Cl[Au-](Cl)(Cl)Cl.[H]O[H].[H]O[H].[H]O[H].[H+] ).Formula: AuCl4H7O3. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:16961-25-4) through the article.

An alk.-acid direct glycerol fuel cell (AA-DGFC) was proposed for a portable power generating device that requires high power d. A good design of cell components and optimum cell operating conditions are the key factors to yield high performance of fuel cells. In this work, AA-DGFC with Pt/C anode catalyst showed outstanding performance with open-circuit voltage as high as 1.72V and the peak power d. of 330 mWcm-2 which is about 2.7 times higher than the performance of a typical anion exchange membrane direct glycerol fuel cell (AEDGFC). The operating conditions providing the best performance were at glycerol to NaOH mole ratio of 1:5, 1.0M glycerol concentration, an anolyte volumetric flow rate of 1mLmin-1 and cell temperature of 80°C. For the design of the cell component, the optimum Nafion ionomer content in the anode microporous layer was 20 wt%. Among the Au-based catalysts at the anode studied Au/C, Au-Ni/C and Au-Ag/C, the Au-Ni/C outperformed the others with the power d. of 142 mWcm-2.

Although many compounds look similar to this compound(16961-25-4)Formula: AuCl4H7O3, numerous studies have shown that this compound(SMILES:Cl[Au-](Cl)(Cl)Cl.[H]O[H].[H]O[H].[H]O[H].[H+]), has unique advantages. If you want to know more about similar compounds, you can read my other articles.

Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

COA of Formula: C7H11NO2. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: tert-Butyl 2-cyanoacetate, is researched, Molecular C7H11NO2, CAS is 1116-98-9, about Double Capture of Difluorocarbene by 2-Aminostyrenes Enables the Construction of 3-(2,2-Difluoroethyl)-2-fluoroindoles. Author is Sheng, Heyun; Su, Jianke; Li, Xin; Li, Xue; Song, Qiuling.

An efficient strategy to construct 3-(2,2-difluoroethyl)-2-fluoroindoles from activated o-aminostyrenes with Et bromodi-fluoroacetate as a difluorocarbene source was reported. Through double capture of a difluorocarbene, two different types of fluorine motifs were incorporated into the products with simultaneous construction of one C-N and two C-C bonds, without the need for transition metals. This reaction features high efficiency and excellent functional group compatibility and had great potential in the late-stage modifications of pharmaceutical mols. and natural products.

Although many compounds look similar to this compound(1116-98-9)COA of Formula: C7H11NO2, numerous studies have shown that this compound(SMILES:O=C(OC(C)(C)C)CC#N), has unique advantages. If you want to know more about similar compounds, you can read my other articles.

Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: Tricyclohexylphosphonium tetrafluoroborate, is researched, Molecular C18H34BF4P, CAS is 58656-04-5, about Pd-Catalyzed Decarboxylative Cross-Coupling of 2-Carboxyazine N-oxides with Various (Hetero)aryl Halides, the main research direction is pyridine quinoline isoquinoline aryl preparation; 2-carboxyazine N-oxides; catalysis; cross-coupling; palladium.Electric Literature of C18H34BF4P.

Decarboxylation cross-coupling reactions of substituted 2-carboxyazine N-oxides, with a variety of heteroaryl halides or aryl halides, by bimetallic Pd0/CuI and Pd0/AgI catalysis are reported. Two possible pathways, a conventional bimetallic-catalyzed decarboxylation-arylation, as well as a protodecarboxylation direct carbon hydrogen bond (C-H bond) arylation sequence have been considered. These methods provide the first general decarboxylation-arylation methodol. for the 2-carboxyazine series. Under optimized conditions the synthesis of the target compounds was achieved using palladium bromide (PdBr2), tricyclohexylphosphine tetrafluoroborate and carbonic acid silver(1+) salt (1:2) (silver carbonate) or copper oxide (Cu2O) as catalyst combination. Starting materials included 2-quinolinecarboxylic acid 1-oxide, 4-methoxy-2-quinolinecarboxylic acid 1-oxide, isoquinoline 2-oxide, 2-pyridinecarboxylic acid 1-oxide. Aryl halides included 3-bromopyridine, bromobenzene, iodobenzene, 2-bromopyrazine, 2-iodopyrazine, 2-iodofuran. The title compds thus formed included biaryls, such as 2,3′-bipyridine 1-oxide, 2-(2-furanyl)pyridine 1-oxide, 2-(4-chlorophenyl)quinoline 1-oxide and related substances.

Although many compounds look similar to this compound(58656-04-5)Electric Literature of C18H34BF4P, numerous studies have shown that this compound(SMILES:F[B-](F)(F)F.[PH+](C1CCCCC1)(C2CCCCC2)C3CCCCC3), has unique advantages. If you want to know more about similar compounds, you can read my other articles.

Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Recommanded Product: 3229-00-3. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: Pentaerythrityltetrabromide, is researched, Molecular C5H8Br4, CAS is 3229-00-3, about Synthesis of star polymethyl acrylate by SET-LRP at ambient temperature. Author is Ding, Wei; Lv, Chongfu; Sun, Ying; Luan, Huoxin; Yu, Tao; Qu, Guangmiao.

The star-shaped polymethyl acrylate (PMA) was synthesized by single electron transfer living radical polymerization (SET-LRP) at 30° in DMSO, using 2,2-dibromomethyl-1,3-dibromopropane as the multi-functional initiator, Cu0 powder and tris-(2-dimethylamino ethyl)amine (Me6-TREN) as catalyst. The structure of polymer was analyzed by 1H NMR, and the results showed that the star-shaped PMA had perfect chain ends (-Br) retention. In addition, the polymerization proceeded smoothly and the time dependence of ln([M]0/[M]) was linear, which could indicate a first order propagation rate with respect to both radicals and monomer concentration, the polymerization was the living polymerization The Mn and Mw/Mn of polymer were being measured by Gel Permeation Chromatog. The kpapp = 0.0367 h-1 and the conversion was 36.3% at 16 h, meanwhile the MnGPC of the polymer was 13,300 and the Mw/Mn was 1.40.

Although many compounds look similar to this compound(3229-00-3)Recommanded Product: 3229-00-3, numerous studies have shown that this compound(SMILES:BrCC(CBr)(CBr)CBr), has unique advantages. If you want to know more about similar compounds, you can read my other articles.

Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 3-Pyridinepropionic acid, is researched, Molecular C8H9NO2, CAS is 3724-19-4, about Heterodinuclear Pt(IV)-Ru(II) anticancer prodrugs to combat both drug resistance and tumor metastasis.Name: 3-Pyridinepropionic acid.

A novel approach to design bimetallic anticancer drug candidates with the capability to combat both drug resistance and tumor metastasis is reported. These water-soluble bifunctional Pt(IV)-Ru(II) heterodinuclear ruthplatin complexes with a unique mode of action display up to 2-orders of magnitude enhanced cytotoxicity in cisplatin-resistant cells and significantly impede cancer cell migration.

Although many compounds look similar to this compound(3724-19-4)Name: 3-Pyridinepropionic acid, numerous studies have shown that this compound(SMILES:OC(=O)CCC1=CC=CN=C1), has unique advantages. If you want to know more about similar compounds, you can read my other articles.

Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: Hydrogen tetrachloroaurate(III) trihydrate( cas:16961-25-4 ) is researched.Related Products of 16961-25-4.Guo, Jiacen; Kim, Ji-Young; Zhang, Mingliang; Wang, Haonan; Stein, Aaron; Murray, Christopher B.; Kotov, Nicholas A.; Kagan, Cherie R. published the article 《Chemo- and Thermomechanically Configurable 3D Optical Metamaterials Constructed from Colloidal Nanocrystal Assemblies》 about this compound( cas:16961-25-4 ) in ACS Nano. Keywords: optical 3D metamaterials constructed colloidal nanocrystal assembly; metamaterials ultrathin lens polarizer waveplates; 3D nanofabrication; broadband circular polarizer; chiral metamaterials; circular dichroism (CD); nanocrystal assembly; nanoimprint; plasmonics. Let’s learn more about this compound (cas:16961-25-4).

Nanofabrication has limited most optical metamaterials to 2D or, often with multiple patterning steps, simple 3D meta-atoms that typically have limited built-in tunability. Here, with a one-step scalable patterning process, we exploit the chem. addressability and structural adaptability of colloidal Au nanocrystal assemblies to transform 2D nanocrystal/Ti bilayers into complex, 3D-structured meta-atoms and to thermally direct their shape morphing and alter their optical properties. By tailoring the length, number, and curvature of 3D helical structures in each meta-atom, we create large-area metamaterials with chiroptical responses of as high as ∼40% transmission difference between left-hand (LCP) and right-hand (RCP) circularly polarized light (ΔT = TRCP – TLCP) that are suitable for broadband circular polarizers and, upon thermally configuring their shape, switch the polarity of polarization rotation. These 3D optical metamaterials provide prototypes for low-cost, large-scale fabrication of optical metamaterials for ultrathin lenses, polarizers, and waveplates.

Although many compounds look similar to this compound(16961-25-4)Related Products of 16961-25-4, numerous studies have shown that this compound(SMILES:Cl[Au-](Cl)(Cl)Cl.[H]O[H].[H]O[H].[H]O[H].[H+]), has unique advantages. If you want to know more about similar compounds, you can read my other articles.

Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

SDS of cas: 1116-98-9. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: tert-Butyl 2-cyanoacetate, is researched, Molecular C7H11NO2, CAS is 1116-98-9, about The role of the π-bridge length in the performance of diketopyrrolopyrrole-based organic dyes for dye-sensitized solar cells.

Three novel diketopyrrolopyrrole-based metal-free organic dyes (TPh, BPh and SPh) with different π-bridge lengths were designed and synthesized for dye-sensitized solar cells (DSSCs). The Ph units were employed as the addnl. π-bridge for the three dyes, which located between the diketopyrrolopyrrole core and cyanoacrylic acid unit. Interestingly, it is the first time to report a diketopyrrolopyrrole-based dye with only one addnl. π-bridge unit (SPh). The effects of π-bridge length on photophys., mol. planarity, energy level and photovoltaic properties of the dyes were systematically investigated. The results revealed that the prolongation of π-bridge length by introducing an addnl. Ph unit results in an extra torsion in the structural framework and reduces the mol. planarity, which has a neg. impact on improving the light-harvesting ability, while it is beneficial in lowering the tendency of aggregation and enhancing the excited electron injection efficiency. Finally, with a moderate π-bridge length (BPh), the best balance of overall performances is achieved, resulting in the highest power conversion efficiency (6.57%) without chenodeoxycholic acid.

Although many compounds look similar to this compound(1116-98-9)SDS of cas: 1116-98-9, numerous studies have shown that this compound(SMILES:O=C(OC(C)(C)C)CC#N), has unique advantages. If you want to know more about similar compounds, you can read my other articles.

Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Recommanded Product: tert-Butyl 2-cyanoacetate. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: tert-Butyl 2-cyanoacetate, is researched, Molecular C7H11NO2, CAS is 1116-98-9, about The GABAB receptor positive allosteric modulator COR659: In vitro metabolism, in vivo pharmacokinetics in rats, synthesis and pharmacological characterization of metabolically protected derivatives. Author is Ferlenghi, Francesca; Maccioni, Paola; Mugnaini, Claudia; Brizzi, Antonella; Fara, Federica; Mostallino, Rafaela; Paola, Castelli M.; Colombo, Giancarlo; Mor, Marco; Vacondio, Federica; Corelli, Federico.

We report an in vitro phase I metabolism study on COR659 (1), a 2-acylaminothiophene derivative able to suppress alc. and chocolate self-administration in rats, likely via pos. allosteric modulation of the GABAB receptor and antagonism/inverse agonism at the cannabinoid CB1 receptor. High performance liquid chromatog. coupled to tandem and high resolution mass spectrometry was employed for the characterization of in vitro metabolism and in vivo pharmacokinetics of COR659 in rats. In vitro [35S]GTPγS binding assays on stimulated GABAB and CB1 receptors, in combination with alc. and chocolate self-administration experiments in rats, were employed to assess the pharmacol. profile of this novel set of analogs, using COR659 as reference compound Eight metabolites of COR659 were discovered in liver microsomal incubates; two of them (M1, M2) were identified by comparison with synthetic reference standards In the novel set of COR659 analogs, those bearing branched alkyl substituents on the ester group, showed an improved in vitro metabolic stability (2-4), had an in vitro GABAB PAM (2-4) and/or CB1 partial agonist/antagonist profile (2-3) and maintained the ability to reduce alc. (2-4) and/or chocolate (4) self-administration in rats. Both PK and PD data ruled out any involvement of metabolite M1 in the in vivo potency of COR659 and 4. The present results, therefore, highlight the importance to design and synthesize novel compounds endowed with the dual activity profile and devoid of metabolic liabilities.

Although many compounds look similar to this compound(1116-98-9)Recommanded Product: tert-Butyl 2-cyanoacetate, numerous studies have shown that this compound(SMILES:O=C(OC(C)(C)C)CC#N), has unique advantages. If you want to know more about similar compounds, you can read my other articles.

Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Application In Synthesis of Pentaerythrityltetrabromide. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: Pentaerythrityltetrabromide, is researched, Molecular C5H8Br4, CAS is 3229-00-3, about Quantum chemisty of pentaerythrityl tetrabromide. Author is Peng, Yong-li; Chen, Bai-guang; Luo, Can; Huang, Zhi-xiong.

Pentaerythritol and benzenesulfonyl chloride, sodium bromide were used as raw materials to prepare 1,3-dibromo-2,2-bis (bromomethyl) propane through a method of two steps. The structure of the product was characterized by IR spectra (FT-IR) and 1H-NMR (1H NMR). 1,3-dibromo-2,2-bis (bromomethyl) propane mol. structure was studied by Gaussian 03 software at quantum chem. level. The geometric configuzation of 1,3-dibromo-2,2-bis (bromomethyl) propane mol. was optimized by d. functional theory at B3LYP/6-31G level, and the FTIR spectrum and 1H NMR spectrum of the mol. were theor. calculated The results show that the optimal mol. structure is four spatial orientation and central symmetry, in which C-Br has a lower bond order and higher activity. The theor. values of FT-IR spectrum and 1H NMR spectrum are consistent with exptl. values.

Although many compounds look similar to this compound(3229-00-3)Application In Synthesis of Pentaerythrityltetrabromide, numerous studies have shown that this compound(SMILES:BrCC(CBr)(CBr)CBr), has unique advantages. If you want to know more about similar compounds, you can read my other articles.

Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem