Month: April 2022

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 87488-84-4, is researched, SMILESS is BrC1=CC=CC=C1N2N=CC=C2, Molecular C9H7BrN2Journal, Article, Angewandte Chemie, International Edition called Cobalt(III)-Catalyzed Aryl and Alkenyl C-H Aminocarbonylation with Isocyanates and Acyl Azides, Author is Li, Jie; Ackermann, Lutz, the main research direction is arene heteroarene alkene isocyanate acyl azide aminocarbonylation cobalt catalyst; amide preparation; CH activation; amides; azides; cobalt; isocyanates.Application In Synthesis of 1-(2-Bromophenyl)-1H-pyrazole.

Expedient C-H aminocarbonylations of unactivated (hetero)arenes and alkenes were accomplished with a cobalt(III) catalyst that shows high functional group tolerance. The C-H functionalization occurred with excellent chemo-, site-, and diastereoselectivity and enabled step-economical reactions with isocyanates or acyl azides.

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Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《The optical resolution of spiroheptanedicarboxylic acid》. Authors are Backer, H. J.; Schurink, J. H. B..The article about the compound:Pentaerythrityltetrabromidecas:3229-00-3,SMILESS:BrCC(CBr)(CBr)CBr).Related Products of 3229-00-3. Through the article, more information about this compound (cas:3229-00-3) is conveyed.

According to van’t Hoff (La chimie dans l’espace, p. 29(1875)) compounds of the types I and II should be capable of being resolved into optical components (cf. Aschan, Ber. 35, 3396(1902)), and the same holds for the spirocyclic compounds of the type III. The present paper deals with the preparation and optical resolution of spiroheptanedicarboxylic acid, giving the 1st example of the optical resolution of a compound of type III. The optical activity of compounds of this type favors the tetrahedric formulation of pentaerythritol, whether regular or not (cf. Böeseken and Felix, C. A. 23, 99, 4672). Pentaerythritol was obtained in excellent yields as follows: 190 g. pulverized CaO is added to 210 g. AcH and 800 g. paraformaldehyde in 5 l. water at 60°, the temperature being kept at 60° for 2 more hrs. after the addition After cooling the solution is decolorized with charcoal, neutralized with HCl and evaporated in vacuo until Ca formate seps.; after filtering the hot solution from this precipitate, the filtrate is cooled in ice and gives a deposit of 350 g. pentaerythritol, m. 257°, while a 2nd crop of 100 g. may be obtained from the mother liquor. Sometimes the 1st product m. 200-20° but one crystallization from dilute HCl yields a product, m. 254°, the lowering of the m. p. of the crude product being probably due to the presence of acetals. For the preparation of tetrabromopentaerythritol, 1 kg. PBr3 is added slowly to 250 g. pentaerythritol, on the water bath; after the addition the mixture is heated for 20 hrs. at 160-80° in an oil bath. The crude product is first freed from the tri-Br compound by washing with cold EtOH and is then extracted with boiling EtOH; yield 86%, m. 162°. On heating 140 g. anhydrous NaI, 70 g. of the tetra-Br compound and 300 cc. acetone for 36 hrs. at 100°, tetraiodoerythritol, m. 233°, is obtained; the same result can be obtained on using MeCOEt as a solvent and boiling for 16 hrs. in an open flask. Crystallographic properties (P. Terpstra): monoclinic crystals, β = 113 ° 43′, a : c = 0.619: 1 ; forms observed : (100); (001); (1̅02) and probably (012) and (210̅); angles: (100):(001) = 66°17′; (1̅02): (001) = 47°37′; the optical axes are situated in the plane (010); the sharp bissectrix is nearly perpendicular to (100). The crystals are analogous to those of tetrabromopentaerythritol for which Jaeger (C. A. 3, 2446) found β = 112°52.5′; a:c = 0.6240: 1. The preparation of spiroheptanedicarboxylic acid has already been described by Fecht (C. A. 3, 75) but the yield could be improved considerably in the following way: 80 g. CH2(CO2Et)2 is added to 11.5 g. Na in 500 cc. AmOH; then 40 g. tetrabromopentaerythritol is added and the EtOH, formed by the replacement of the Et group by the Am group in the CH2(CO2Et)2 is removed by distillation until the b. p. reaches 128°, the mixture being finally boiled for 40-50 hrs. The larger part of the AmOH is then distilled off, the remainder being removed by distillation with steam. The remaining ester is then saponified with alc. KOH, a mixture of spiroheptanetetra- and -dicarboxylic acids being formed in which the tetra-compound predominates. On heating the mixture at 200-20°, decarboxylation takes place with the formation of spiroheptanedicarboxylic acid, m. 212°; yield, 75-80%. On carrying out the same reaction with tetraiodoerythritol, a yield of only 20% is obtained. On boiling the acid for 2 hrs. with an excess of aniline, spiroheptanedicarboxanilide, m. 228°, was obtained. After the saponification of the primary reaction product at room temperature with alc. KOH, spiroheptanetetracarboxylic acid, m. 219°, is obtained; normal Ba salt (7 H2O) shows a solubility of 0.068% at 25°. The optical resolution of the dicarboxylic acid was carried out with the normal brucine salt (6 H2O), m. 133°, either by “”cold crystallization”” (cf. Backer and Burgers, C. A. 19, 1128) or in the usual way; normal strychnine salt, m. 238°. After 9 crystallizations of the brucine salt from hot water the optically pure d-rotatory compound is obtained, the following rotations being observed for the NH4 salt: (M)656.3 1.9°, (M)589.5 2.3°, (M)546.3 2.6°, (M)486.1 3.4°. The free acid shows in ether (M)D 1.9°. The optically active compound could not be racemized either by heating the NH4 salt for 12 hrs. at 100° in H2O, or by heating with 0.75 N NaOH during the same time at that temperature

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Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Computed Properties of C5H8Br4. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: Pentaerythrityltetrabromide, is researched, Molecular C5H8Br4, CAS is 3229-00-3, about Study of the reaction of the styryl carbanion with 1,3-dibromo-2,2-dibromomethylpropane. Author is Beinert, Gerard; Herz, Jean.

The reaction was studied of styryl carbanions with C(CH2Br)3 [3229-00-3]. A linear product of twice the mol. weight of the precursor and a Br-containing polymer of the same mol. weight as the precursor were obtained. The results were independent of the nature of the solvent and of the cation. The reaction was also studied of potassiophenylethane [2678-95-7] with C(CH2Br)3.

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Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Spiranes. X. 2,2′,3,3′-Tetrahydro-3,3′-spirobis[4H-1,5-benzo-oxathiepine]. Topological equivalency of the diastereoisomers, published in 1973, which mentions a compound: 3229-00-3, mainly applied to spirobisbenzooxathiepine conformation; NMR spirobisbenzooxathiepine; cycloaddition tetrabromoneopentane monothiocatechate, Computed Properties of C5H8Br4.

The title compound (I) was prepared (2%) by heating a Cellosolve solution of o-NaSC6H4ONa with C(CH2Br)4 in sealed glass tube for 100 hr at 160°. The structure of the product was confirmed by ir, uv, and NMR spectra. The preferable conformations were determined by NMR.

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Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 16961-25-4, is researched, Molecular AuCl4H7O3, about Formation of Si nanorods and discrete nanophases by axial diffusion of Si from substrate into Au and AuPt nanoalloy nanorods, the main research direction is silicon gold platinum nanoalloy nanorod nanophase axial diffusion; 1D-nanostructures; AAO thin films; Au nanoparticles; Au nanorods; AuPt nanoalloy; Pt nanorods; Si nanorods; diffusion; electrodeposition in AAO; platinum silicide.Reference of Hydrogen tetrachloroaurate(III) trihydrate.

Interdiffusion between Si substrate and nanorod arrays of Au, Pt, and AuPt nanoalloys is investigated at temperatures lower than the AuSi eutectic temperature When the nanorod is pure Au, Si diffusion from the substrate is very rapid. Au atoms are completely replaced by Si, converting the nanostructure into one of Si nanorod arrays. Au is diffused out to the substrate. The Au nanorod arrays on Si are unstable. When the nanorod is pure Pt, however, no diffusion of Si into the nanorod or any silicide formation is observed The Pt nanorods are stable on Si substrate. When the nanorods are an alloy of AuPt, interesting interactions occur. Si diffusion into the nanorods is rapid but the diffusing Si readily reacts with Pt forming PtSi while Au diffuses out to the substrate. After annealing, nanophases of Au, Pt, PtSi, and Si may be present within the nanorods. When the Pt content of the alloy is low (12 at%) all Pt atoms are converted to silicide and the extra Si atoms remain in elemental form, particularly near the tip of the nanorods. Hence, the presence of Au accelerates Si diffusion and the ensuing reaction to form PtSi, a phenomenon absents in pure Pt nanorods. When the Au content of the alloy is low, the Si diffusion would cease when all Au atoms have diffused out of the nanorod, thereby arresting the silicide formation resulting in excess Pt in elemental form within the nanorod. This is a technique of making Si nanorods with and without embedded PtSi nanophase consisting of heterojunctions which could have unique properties.

There are many compounds similar to this compound(16961-25-4)Reference of Hydrogen tetrachloroaurate(III) trihydrate. if you want to know more, you can check out my other articles. I hope it will help you，maybe you’ll find some useful information.

Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: Hydrogen tetrachloroaurate(III) trihydrate, is researched, Molecular AuCl4H7O3, CAS is 16961-25-4, about Improvement of the carbon monoxide gas sensing properties of polyaniline in the presence of gold nanoparticles at room temperature, the main research direction is carbon monoxide gas sensor polyaniline gold nanocomposite.Reference of Hydrogen tetrachloroaurate(III) trihydrate.

In the present work, the influence of gold (Au) nanoparticles on carbon monoxide gas sensing performance of polyaniline (PAni) at room temperature was comprehensively studied. The Au/PAni nanocomposites were synthesized by the ultrasound mixing of emeraldine salt polyaniline and different amounts of Au nanoparticles colloidal solution The analyses of field emission scanning electron microscope in conjunction with energy-dispersive X-ray spectroscopy indicated that the surface of PAni fibers was well decorated with Au nanoparticles due to the electrostatic interaction and hydrogen bonding. Then, the gas sensing performance of all sensors was investigated toward various concentrations of carbon monoxide gas ranging from 200 to 6000 ppm at room temperature The results indicated that the 2.5%Au/PAni sensor possesses high response(14%-1000 ppm), low detection limit(33 ppm), the acceptable response time(180 s), wide dynamic range(200-6000 ppm) and good selectivity owing to catalytic properties of Au nanoparticles. Thus, the one-dimensional nanostructure might give a promise for high-performance sensing applications.

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Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: tert-Butyl 2-cyanoacetate, is researched, Molecular C7H11NO2, CAS is 1116-98-9, about Discovery, structure-activity relationship study and biological evaluation of 2-thioureidothiophene-3-carboxylates as a novel class of C-X-C chemokine receptor 2 (CXCR2) antagonists, the main research direction is cancer CXCR2 antagonist CXCL8 ERK beta arrestin phosphorylation recruitment; CXCL8; CXCR2; GPCR; Thioureidothiophene; cAMP; β-arrestin.Quality Control of tert-Butyl 2-cyanoacetate.

The C-X-C motif ligand 8 and C-X-C chemokine receptor 2 (CXCL8-CXCR2) axis is involved in pathogenesis of various diseases including inflammation and cancers. Various CXCR2 antagonists are under development for several diseases. Our previous high-throughput cell-based assay specific for CXCR2 has identified a pyrimidine-based compound CX797 acting on CXCR2 down-stream signaling. A lead optimization campaign through scaffold-hopping strategy led to a series of 2-thioureidothiophene-3-carboxylates (TUTP) as novel CXCR2 antagonists. Structure-activity relationship study of TUTPs led to the identification of compound 52(I) that significantly inhibited CXCR2-mediated β-arrestin recruitment signaling (IC50 = 1.1±0.01 μM) with negligible effect on CXCL8-mediated cAMP signaling and calcium flux. Similar to the known CXCR2 antagonist SB265610, compound 52 inhibited CXCL8-CXCR2 induced phosphorylation of ERK1/2. TUTP compounds also inhibited CXCL8-mediated cell migration and showed synergy with doxorubicin in ovarian cancer cells, thereby supporting TUTPs as promising compounds for cancer treatment.

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Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 16961-25-4, is researched, SMILESS is Cl[Au-](Cl)(Cl)Cl.[H]O[H].[H]O[H].[H]O[H].[H+], Molecular AuCl4H7O3Journal, Article, Research Support, Non-U.S. Gov’t, Scientific Reports called Antimicrobial activities of green synthesized gums-stabilized nanoparticles loaded with flavonoids, Author is Anwar, Ayaz; Masri, Abdulkader; Rao, Komal; Rajendran, Kavitha; Khan, Naveed Ahmed; Shah, Muhammad Raza; Siddiqui, Ruqaiyyah, the main research direction is gum stabilized nanoparticle flavonoid green synthesis antimicrobial activity.HPLC of Formula: 16961-25-4.

Herein, we report green synthesized nanoparticles based on stabilization by plant gums, loaded with citrus fruits flavonoids Hesperidin (HDN) and Naringin (NRG) as novel antimicrobial agents against brain-eating amoebae and multi-drug resistant bacteria. Nanoparticles were thoroughly characterized by using zetasizer, zeta potential, at. force microscopy, ultravoilet-visible and Fourier transform-IR spectroscopic techniques. The size of these spherical nanoparticles was found to be in the range of 100-225 nm. The antiamoebic effects of these green synthesized Silver and Gold nanoparticles loaded with HDN and NRG were tested against Acanthamoeba castellanii and Naegleria fowleri, while antibacterial effects were evaluated against methicillin-resistant Staphylococcus aureus (MRSA) and neuropathogenic Escherichia coli K1. Amoebicidal assays revealed that HDN loaded Silver nanoparticles stabilized by gum acacia (GA-AgNPs-HDN) quant. abolished amoeba viability by 100%, while NRG loaded Gold nanoparticles stabilized by gum tragacanth (GT-AuNPs-NRG) significantly reduced the viability of A. castellanii and N. fowleri at 50μg per mL. Furthermore, these nanoparticles inhibited the encystation and excystation by more than 85%, as well as GA-AgNPs-HDN only completely obliterated amoeba-mediated host cells cytopathogenicity. Whereas, GA-AgNPs-HDN exhibited significant bactericidal effects against MRSA and E. coli K1 and reduced bacterial-mediated host cells cytotoxicity. Notably, when tested against human cells, these nanoparticles showed minimal (23%) cytotoxicity at even higher concentration of 100μg per mL as compared to 50μg per mL used for antimicrobial assays. Hence, these novel nanoparticles formulations hold potential as therapeutic agents against infections caused by brain-eating amoebae, as well as multi-drug resistant bacteria, and recommend a step forward in drug development.

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Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 58656-04-5, is researched, SMILESS is F[B-](F)(F)F.[PH+](C1CCCCC1)(C2CCCCC2)C3CCCCC3, Molecular C18H34BF4PJournal, Article, Research Support, Non-U.S. Gov’t, Chemistry – A European Journal called Discovery of a Full-Color-Tunable Fluorescent Core Framework through Direct C-H (Hetero)arylation of N-Heterocycles, Author is Liu, Bo; Wang, Zhi; Wu, Ningjie; Li, Mingliang; You, Jingsong; Lan, Jingbo, the main research direction is full color tunable fluorescent core framework manufacturing.Formula: C18H34BF4P.

Metal-catalytic direct C-H arylation of N-heterocycles can serve as a highly efficient and easily tunable synthetic tool for the discovery of a structurally diverse of organic fluorescent substances, especially indolizines. The prepared fluorophores have successfully marked A375 cells, exhibiting their future potential as useful bioimaging fluorescence probes.

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Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Cerra, Sara; Salamone, Tommaso A.; Sciubba, Fabio; Marsotto, Martina; Battocchio, Chiara; Nappini, Silvia; Scaramuzzo, Francesca A.; Li Voti, Roberto; Sibilia, Concita; Matassa, Roberto; Beltran, Ana Maria; Familiari, Giuseppe; Fratoddi, Ilaria researched the compound: Hydrogen tetrachloroaurate(III) trihydrate( cas:16961-25-4 ).COA of Formula: AuCl4H7O3.They published the article 《Study of the interaction mechanism between hydrophilic thiol capped gold nanoparticles and melamine in aqueous medium》 about this compound( cas:16961-25-4 ) in Colloids and Surfaces, B: Biointerfaces. Keywords: hydrophilic thiol gold nanoparticle melamine UV spectroscopy; 3-mercapto-1-propanesulfonate; Aggregation mechanism; Electrostatic interactions; Hydrophilic gold nanoparticles; Melamine. We’ll tell you more about this compound (cas:16961-25-4).

In the last years, intense efforts have been made in order to obtain colloidal-based systems capable of pointing out the presence of melamine in food samples. In this work, we reported about the recognition of melamine in aqueous solution, using gold nanoparticles stabilized with 3-mercapto-1-propanesulfonate (AuNPs-3MPS), with the aim of deepening how the recognition process works. AuNPs were synthesized using a wet chem. reduction method. The synthesized AuNPs-3MPS probe was fully characterized, before and after the recognition process, by both physicochem. (UV-vis, FT-IR, 1H-NMR, DLS and ζ-potential) and morphostructural techniques (AFM, HR-TEM). The chem. and electronic structure was also investigated by SR-XPS. The sensing method is based on the melamine-induced aggregation of AuNPs; the presence of melamine was successfully detected in the range of 2.5-500 ppm. The results achieved also demonstrate that neg. charged AuNPs-3MPS are potentially useful for determining melamine contents in aqueous solution SR-XPS measurements allowed to understand interaction mechanism between the probe and the analyte. The presence of sulfonate groups allows a mutual interaction mediated by electrostatic bonds between nanoparticles surface thiols and pos. charged amino groups of melamine mols.

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Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem