Explore more uses of cas: 5805-39-0 | New Journal of Chemistry

2-(1H-Benzo[d]imidazol-2-yl)aniline(cas:5805-39-0 Reference of 2-(1H-Benzo[d]imidazol-2-yl)aniline) is a chemical reagent used in the synthesis of small molecule inhibitors targeting ubiquitin-like domains for treatments of diseases caused by the cellular accumulation of damaged proteins.

Si, Wei-Jie;Wang, Xiao-Bin;Chen, Min;Wang, Meng-Qi;Lu, Ai-Min;Yang, Chun-Long published 《Design, synthesis, antifungal activity and 3D-QSAR study of novel pyrazole carboxamide and niacinamide derivatives containing benzimidazole moiety》 in 2019. The article was appeared in 《New Journal of Chemistry》. They have made some progress in their research.Reference of 2-(1H-Benzo[d]imidazol-2-yl)aniline The article mentions the following:

A series of novel pyrazole carboxamide I (R1 = H, Cl, Me; R2 = Me, CF3), II (R1 = H, Cl, Me; R2 = Me, i-Bu) and niacinamide derivatives III (R1 = H, Cl, Me; R2 = H, Cl, SH) containing a benzimidazole moiety were designed and synthesized as antifungal candidate agents. The structure of compound I (R1 = H; R2 = Me) was confirmed by single crystal X-ray diffraction anal. The antifungal activities of the target compounds were evaluated in vitro against four phytopathogenic fungi (namely Botrytis cinerea, Rhizoctonia solani, Fusarium graminearum and Alternaria solani) by the mycelium growth inhibition method. The bioassay results indicated that some of the compounds exhibited good antifungal activity against B. cinerea at 100 μg ML-1 compared to other three fungi. In order to better explore the structure-activity relationship (SAR), the EC50 values of target compounds against B. cinerea were measured and assessed. Subsequently, a 3D quant. structure-activity relationship (3D-QSAR) study was carried out using the comparative mol. field anal. (CoMFA) technique based on the inhibitory activities of tested compounds against B. cinerea. Mol. modeling results revealed fine predictive ability with cross-validated q2 and non-cross-validated r2 values of 0.578 and 0.850, resp. The experimental procedure involved many compounds, such as 2-(1H-Benzo[d]imidazol-2-yl)aniline (cas: 5805-39-0) .

2-(1H-Benzo[d]imidazol-2-yl)aniline(cas:5805-39-0 Reference of 2-(1H-Benzo[d]imidazol-2-yl)aniline) is a chemical reagent used in the synthesis of small molecule inhibitors targeting ubiquitin-like domains for treatments of diseases caused by the cellular accumulation of damaged proteins.

Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem