Imidazole is a heterocyclic compound with a five-membered planar ring. It is amphoteric and highly polar. 1739-84-0, formula is C5H8N2, Name is 1,2-Dimethyl-1H-imidazole. The pharmacophore of imidazole exists in bioactive compounds including amino acids, plant growth regulators and therapeutic agents. Formula: C5H8N2.
Firooz, Sepideh Khaki;Wahab, M. Farooq;Yu, Jeongjae;Armstrong, Daniel W. research published 《 High efficiency functionalized hydrophilic cyclofructans as stationary phases in sub/supercritical fluid chromatography》, the research content is summarized as follows. Packed column SFC has become very popular for preparative and anal. separations due to the low cost of CO2, its accessible critical temperature, and pressure, with the addnl. benefit of a low environmental burden. Currently, there is a shortage of new polar stationary phase chemistries for SFC. In this work, two new functionalized cyclofructan columns are introduced and evaluated for their performance in achiral SFC separations for the first time. Cyclofructan (CF6), a macrocyclic oligosaccharide, was covalently linked with benzoic acid (BCF6) and Pr sulfonic acid (SCF6) groups by ether bonds. Superficially porous particles (2.7 μm) bonded with modified CF6 showed markedly different selectivity than native CF6. In SFC, peak shapes of amines and basic compounds are often compromised. We show that small quantities (∼5.7% volume/volume) of water added to the methanol modifier in CO2 improves peak symmetries of primary, secondary, and tertiary amines. Efficiencies as high as 200,000 plates/m (reduced plate height ∼ 1.8) were observed for benzamide and amitriptyline on the BCF6 column. The relative standard deviations (RSDs) of retention times on BCF6 were about 1.4%, and on SCF6 were less than 1%. Amines on the SCF6 column showed plate counts as high as 170,000 plates/m. Tetramethylammonium acetate is examined as an alternative to water in MeOH. A run time of 36 min with methanol, trifluoroacetic acid, triethylamine mobile phase was reduced to <5 min with complete baseline resolution for a set of amines. The new stationary phases allow greener approaches towards solving separation problems.
Formula: C5H8N2, 1,2-Dimethylimidazole is used in the synthesis of 1,2-dimethyl-3-n-butylimidazoliumchloride and 1,2-dimethyl-3-n-propylimidazolium chloride. It also can be used in the synthesis of 1-(2-methoxyethyl)-2,3-dimethylimidazolium chloride and hexafluorophosphate salts.
1,2-Dimethylimidazole is a heterocyclic compound that contains nitrogen and carbon. It can be produced by the reaction between glyoxal and fatty acid in the presence of a base. 1,2-Dimethylimidazole has been shown to have biological properties such as an antioxidant effect. It is also used as a chemical intermediate for production of other chemicals such as 2-methylimidazole and 3-methylimidazole. 1,2-Dimethylimidazole has been shown to react with metal carbonyls to produce methylimines, which are useful intermediates in organic synthesis. The reaction mechanism involves hydrogen bonding and steric interactions between the imidazole ring and the metal carbonyl reactant., 1739-84-0.
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem