Imidazole Biochem/physiol Actions: Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division. 10111-08-7, formula is C4H4N2O, Name is 1H-Imidazole-2-carbaldehyde. It also acts as a microtubule destabilizing agents and inhibits topoisomerase and Cytochrome P450 Family 26 Subfamily A Member 1 (CYP26A1) enzymes. Related Products of 10111-08-7.
Hunter, Kelly M.;Wagner, Jackson C.;Kalaj, Mark;Cohen, Seth M.;Xiong, Wei;Paesani, Francesco research published 《 Simulation Meets Experiment: Unraveling the Properties of Water in Metal-Organic Frameworks through Vibrational Spectroscopy》, the research content is summarized as follows. In nanoporous materials, host-guest interactions affect the properties and function of both adsorbent and adsorbate mols. Because of their structural and chem. diversity, metal-organic frameworks (MOFs), a common class of nanoporous materials, have been shown to be able to efficiently and, often, selectively adsorb various types of guest mols. In this study, we characterize the structure and dynamics of water confined in ZIF-90. Through the integration of exptl. and computational IR (IR) spectroscopy, we probe the structure of heavy water (D2O) adsorbed in the pores, disentangling the fundamental framework-water and water-water interactions. The exptl. IR spectrum of D2O in ZIF-90 displays a blue-shifted OD-stretch band compared to that of liquid D2O. The anal. of the IR spectra simulated at both classical and quantum levels indicates that the D2O mols. preferentially interact with the carbonyl groups of the framework and highlights the importance of including nuclear quantum effects and taking into account Fermi resonances for a correct interpretation of the OD-stretch band in terms of the underlying hydrogen-bonding motifs. Through a systematic comparison with the exptl. spectra, we demonstrate that computational spectroscopy can be used to gain quant., mol.-level insights into framework-water interactions that determine the water adsorption capacity of MOFs as well as the spatial arrangements of the water mols. inside the MOF pores which, in turn, are key to the design of MOF-based materials for water harvesting.
10111-08-7, 1H-Imidazole-2-carbaldehyde, also known as 1H-Imidazole-2-carbaldehyde, is a useful research compound. Its molecular formula is C4H4N2O and its molecular weight is 96.09 g/mol. The purity is usually 95%.
1H-Imidazole-2-carboxaldehyde is a novel PTP1b inhibitor with potential application to treat type 2 diabetes.
1H-Imidazole-2-carboxaldehyde is a broad-spectrum antimicrobial that has been shown to inhibit the growth of bacteria by interfering with protein synthesis. It binds to the cytosolic protein and receptor molecule, which are involved in the activation of bacterial enzymes. Imidazole-2-carboxaldehyde reacts with anhydrous sodium and copper complex to produce hydrogen bonds, which prevent the formation of the nitrogen atoms necessary for cellular processes. This chemical also has biological properties such as glyoxal, which inhibits bacterial growth by reacting with amino groups on proteins., Related Products of 10111-08-7
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem