Godefroi, E. F.; Loozen, H. J. J.; Luderer-Platje, J. Th. J. Mrs. published the artcile< Synthesis of 1,2-disubstituted imidazole-5-carboxaldehydes and-4,5-dicarboxaldehydes>, Application In Synthesis of 36947-69-0, the main research area is formylation imidazole; imidazotropones; imidazopyridazine; pyridazine imidazo.
1,2-Disubstituted imidazoles react with refluxing 37% CH2O in Ac2O-NaOAc buffer. Both 5-hydroxymethyl- and 4,5-bis(hydroxymethyl)imidazole derivatives are formed in 25-50% yields. Bis(hydroxymethylation) is favored by prolonged reaction and is dependent upon the nature of the C-2 substituent. Oxidation of the mono- and dihydroxymethylimidazoles by Pb(OAc)4 in pyridine affords the imidazole-mono- and -dicarboxaldehydes. A few reactions of 1-benzyl-2-isopropylimidazole-4,5-dicarboxaldehyde (I) with certain ketones and with hydrazine are described.
Recueil des Travaux Chimiques des Pays-Bas published new progress about 36947-69-0. 36947-69-0 belongs to class imidazoles-derivatives, and the molecular formula is C7H12N2, Application In Synthesis of 36947-69-0.
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem