Ohba, Masashi; Mukaihira, Takafumi; Fujii, Tozo published the artcile< Preparatory study for the synthesis of the starfish alkaloid imbricatine. Syntheses of 5-arylthio-3-methyl-L-histidines>, HPLC of Formula: 1003-21-0, the main research area is asym synthesis arylthiomethylhistidine; histidine arylthio asym synthesis; formal synthesis starfish alkaloid imbricatine; ovothiol A C formal synthesis.
Chiral syntheses of 3-methyl-5-(arylthio)-L-histidines I (R = Ph, 1-naphthyl), selected as models for the asteroid alkaloid imbricatine, have been accomplished through a 10-step route starting from 4(5)-bromoimidazole (II). The key steps involved were methylation of II, hydroxymethylation of 4-bromo-1-methyl-1H-imidazole, replacement of the 4-bromo group by an arylthio group, and introduction of a chiral α-amino acid moiety into the chlorides III by the bislactim ether method. The synthesis of 4-(4-methoxybenzyl)thio analog III (R = 4-MeOC6H4CH2), carried out in a similar manner, concluded formal syntheses of ovothiols A and C.
Chemical & Pharmaceutical Bulletin published new progress about Stereoselective synthesis. 1003-21-0 belongs to class imidazoles-derivatives, and the molecular formula is C4H5BrN2, HPLC of Formula: 1003-21-0.
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem