In 2018,Bente, Stefanie; Kampert, Florian; Tan, Tristan T. Y.; Hahn, F. Ekkehardt published 《Site-selective metallation of dicarbene precursors》.Chemical Communications (Cambridge, United Kingdom) published the findings.Formula: C7H5ClN2 The information in the text is summarized as follows:
An imidazolium/2-chlorobenzimidazole bis-NHC precursor was reacted with Ag2O followed by transmetalation with [AuCl(THT)] to give the Au-NHC complex via metalation of the imidazolium site, while the reaction of the same bis-NHC precursor with [Pd(PPh3)4] yields exclusively the azolato complex by oxidative addition of the C2-Cl bond to Pd0. Both complexes were converted into the heterobimetallic Au/Pd-complex by reaction with [Pd(PPh)3]4 (for the NHC complex) or Ag2O/[AuCl(THT)] (for the azolato complex), resp. The experimental part of the paper was very detailed, including the reaction process of 2-Chloro-1H-benzo[d]imidazole(cas: 4857-06-1Formula: C7H5ClN2)
2-Chloro-1H-benzo[d]imidazole(cas: 4857-06-1) binds to monoclonal antibodies, inhibiting their binding to their corresponding antigens. This activity may be due to its ability to bind covalently with amino groups on proteins and other molecules.Formula: C7H5ClN2
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem