In 1989,Danovich, D. K.; Turchaninov, V. K. published 《Basicity of azoles. 2. Relationship with the energy of nonbonding electrons and reorganization energy of the π- and σ-electronic systems of the base upon ionization and protonation》.Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya published the findings.SDS of cas: 16681-56-4 The information in the text is summarized as follows:
Linear relationships between proton affinity (AM1) and ionization potential (Green’s function AM1 quantum-chem. method) were observed for series of imidazoles and pyrazoles and explained with a thermodn. cycle which took explicit account of the differences in electronic reorganization (relaxation) energy of the π- and σ-electronic systems of the azole cation and cation radical relative to the neutral mol. The results came from multiple reactions, including the reaction of 2-Bromo-1H-imidazole(cas: 16681-56-4SDS of cas: 16681-56-4)
2-Bromo-1H-imidazole(cas: 16681-56-4) is a member of imidazole. Its exclusive structural characteristics with enviable electron-rich features are favorable for imidazole-based fused heterocycles to bind efficiently with an array of enzymes and receptors in biological systems through various weak interactions like hydrogen bonds, ion-dipole, cation-π, π-π stacking, coordination, Van der Waals forces, hydrophobic effects, etc., and therefore they demonstrate widespread bioactivities. SDS of cas: 16681-56-4
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem