Mishra, Shashank Shekher; Sharma, C. S. published their research in Indian Journal of Heterocyclic Chemistry in 2021. The article was titled 《Design, synthesis, cytotoxicity, and molecular docking studies of new benzimidazole hybrids as possible anticancer agents》.Safety of 2-Chloro-1H-benzo[d]imidazole The article contains the following contents:
A new anticancer agents, benzimidazole-based morpholine, thiomorpholine and piperazine hybrid compounds I [R = 4-HOC6H4CH2, 4-MeOC6H4CH2, 4-MeC(O)OC6H4CH2, 4-B(OH)2C6H4CH2, 1-[(4-pyrrol-1-ylphenyl)methyl], (4-pyrazol-1-ylphenyl)methyl; R1 = morpholino, thiomorpholino, 4-methylpiperazin-1-yl] were designed and synthesized. The structures of the synthesized compounds were confirmed by Proton NMR, Carbon-13 NMR and mass spectroscopy. The title compounds were screened for cytotoxicity against breast and lung cancer cell lines. Compound I [R = 4-B(OH)2C6H4CH2; R1 = morpholino] was found most active against lung cancer cell line with IC50 value of 2.11μM and compound I [R = 4-B(OH)2C6H4CH2; R1 = 4-methylpiperazin-1-yl] was found most active against breast cancer cell line with IC50 of 2.23μM. The mol. docking anal. was also carried out to explore binding pattern of compound with the target protein. All synthesized compounds showed excellent binding affinity toward target protein. In the experimental materials used by the author, we found 2-Chloro-1H-benzo[d]imidazole(cas: 4857-06-1Safety of 2-Chloro-1H-benzo[d]imidazole)
2-Chloro-1H-benzo[d]imidazole(cas: 4857-06-1) binds to monoclonal antibodies, inhibiting their binding to their corresponding antigens. This activity may be due to its ability to bind covalently with amino groups on proteins and other molecules.Safety of 2-Chloro-1H-benzo[d]imidazole
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem