Reference of Chloro{1,3-bis[2,6-bis(1-methylethyl)phenyl]-4,5-dihydroimidazol-2-ylidene}gold(I)On October 16, 2013 ,《Gold-Mediated Expulsion of Dinitrogen from Organic Azides》 was published in Journal of the American Chemical Society. The article was written by Dash, Chandrakanta; Yousufuddin, Muhammed; Cundari, Thomas R.; Dias, H. V. Rasika. The article contains the following contents:
Organoazides and their nitrogen expulsion chem. have attracted the attention of many scientists because they serve as a useful source of nitrene fragments and interesting nitrene rearrangement products. Gold-mediated reactions are also of significant current interest. This manuscript describes several important discoveries based at the intersection of these fields. In particular, the authors report the first isolable gold organoazides ([(SIPr)-AuN-(1-Ad)-NN][SbF6], [(SIPr)-AuN-(2-Ad)-NN][SbF6] and [(SIPr)-AuN-(Cy)-NN][SbF6]; SIPr = a N-heterocyclic carbene; 1-AdNNN = 1-azido-adamantane; 2-AdNNN = 2-azidoadamantane; CyNNN = azidocyclohexane), and their gold-mediated nitrogen expulsion chem., and the isolation of formal nitrene rearrangement products of 1-AdN, 2-AdN and CyN (including the elusive 4-azahomoadamant-3-ene) as their gold complexes. The authors have also performed a computational study to understand and explain the observed structure of gold-coordinated 1-AdNNN and 2-AdNNN and their nitrogen elimination pathways, which implies that the conversion of the organoazide complex to the imine is a concerted process without a nitrene/nitrenoid intermediate. Kinetic studies of [(SIPr)-AuN-(2-Ad)-NN][SbF6] from 30 to 50 °C indicate that nitrogen elimination is a first-order process. The exptl. determined activation parameters are in good agreement with the calculated values. The experimental part of the paper was very detailed, including the reaction process of Chloro{1,3-bis[2,6-bis(1-methylethyl)phenyl]-4,5-dihydroimidazol-2-ylidene}gold(I)(cas: 852445-84-2Reference of Chloro{1,3-bis[2,6-bis(1-methylethyl)phenyl]-4,5-dihydroimidazol-2-ylidene}gold(I))
Chloro{1,3-bis[2,6-bis(1-methylethyl)phenyl]-4,5-dihydroimidazol-2-ylidene}gold(I)(cas: 852445-84-2) belongs to imidazoles.Imidazole rings are also present in imidazole ring alkaloids, which are potential therapeutics for thrombosis, cancer and inflammatory diseases.Reference of Chloro{1,3-bis[2,6-bis(1-methylethyl)phenyl]-4,5-dihydroimidazol-2-ylidene}gold(I) Although other azole heterocycles are ubiquitous in a wide range of biologically active natural products, imidazole rings occur predominantly in the natural amino acid histidine.
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem