Geraschenko, Oleksandr V.; Solomin, Vitalii V.; Vashchenko, Bohdan V.; Khodakivskyi, Pavlo; Tolmachev, Andrey A.; Grygorenko, Oleksandr O. published the artcile< Synthesis and chemical transformations of diazolyl α,α-difluoroacetates>, HPLC of Formula: 1003-21-0, the main research area is hetaryl difluoroacetate preparation chem transformation; glyoxylate hetaryl deoxofluorination.
Optimized protocols for the synthesis of diazolyl α,α-difluoroacetates RC(F)2C(O)OEt (R = 1-methyl-1H-imidazol-2-yl, 1,3-thiazol-2-yl, 1-methyl-1H-1,3-benzodiazol-2-yl, etc.) via deoxofluorination of the corresponding glyoxylates RC(O)C(O)OEt with Morph-DAST are described. The method allowed the preparation of the title fluoridated building blocks in 73-96% yield on up to 15 g scale. Utility of the hetaryl α,α-difluoroacetates was demonstrated by the synthesis of advanced building blocks for medicinal chem., i.e. carboxylic acids RC(F)2C(O)OH/RC(F)2C(O)OH.HCl, amides RC(F)2C(O)NH2, nitriles RC(F)2CN, and alcs. RC(F)2CH2OH.
Journal of Fluorine Chemistry published new progress about Aromatic amides Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 1003-21-0 belongs to class imidazoles-derivatives, and the molecular formula is C4H5BrN2, HPLC of Formula: 1003-21-0.
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem