The author of 《C-N bond forming reactions in the synthesis of substituted 2-aminoimidazole derivatives》 were Gomez-SanJuan, Asier; Botija, Jose Manuel; Mendez, Almudena; Sotomayor, Nuria; Lete, Esther. And the article was published in ARKIVOC (Gainesville, FL, United States) in 2014. Name: Methyl 2-(methylthio)-4,5-dihydro-1H-imidazole-1-carboxylate The author mentioned the following in the article:
Carbon-nitrogen bond forming reactions oriented to the synthesis of 2-amino-imidazolidine derivatives and imidazole derivatives were investigated. The C-2 amination of imidazolidinone by corresponding 2-chlorodihydroimidazole derivatives led to 2-(benzylamino)dihydroimidazole or bis(dihydroimidazole)amine derivatives by choosing the adequate exptl. conditions. On the other hand, the use of N-acyl-2-methylsulfanyldihydroimidazoles allowed carrying out the reactions with aromatic amines, such as p-anisidine. Finally, a palladium catalyzed Buchwald-Hartwig amination was the method of choice for C-N coupling between 2-haloimidazoles and aromatic amines in the synthesis of the corresponding imidazoles. The title compounds thus formed included a 1H-imidazol-2-amine derivative (I) and related substances, 4,5-dihydro-N-(phenylmethyl)-1H-imidazol-2-amine, 1-[4,5-dihydro-2-(methylthio)-1H-imidazol-1-yl]ethanone, 4,5-dihydro-2-(methylthio)-1H-imidazole-1-carboxylic acid Me ester. The synthesis of the target compounds was achieved using 2-imidazolidinone and 2-imidazolidinethione as starting materials. The experimental part of the paper was very detailed, including the reaction process of Methyl 2-(methylthio)-4,5-dihydro-1H-imidazole-1-carboxylate(cas: 60546-77-2Name: Methyl 2-(methylthio)-4,5-dihydro-1H-imidazole-1-carboxylate)
Methyl 2-(methylthio)-4,5-dihydro-1H-imidazole-1-carboxylate(cas: 60546-77-2) belongs to imidazoles.Imidazole rings are part of unnatural cyclic peptides and are used as ester isosteres in peptidomimetic studies.
Name: Methyl 2-(methylthio)-4,5-dihydro-1H-imidazole-1-carboxylate However, the application of imidazoles is not limited to the field of peptides and peptidomimetics.
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem