V., Paleri Sandhya; V., Kakkotakath Muhammad Niyas; R., Karickal Haridas published their research in Research Journal of Chemistry and Environment in 2021. The article was titled 《Microwave assisted synthesis of benzimidazole derivatives using tetra butyl ammonium chloride as phase transfer catalyst, characterization, biological activities and molecular docking studies》.HPLC of Formula: 4857-06-1 The article contains the following contents:
Benzimidazole and its derivatives are of wide interest because of their diverse biol. activity and clin. applications. The heterocyclic imidazole core is a common moiety in a large number of natural products and pharmacol. active compounds and because of that they are possessing inhibitory activity as well as favorable selectivity ratio. Benzimidazoles exhibit significant activities like anti-microbial, anti-viral, anti-diabetic, anti-cancer activity, numerous antioxidants, anti-parasitic, anti-helmintics, antiproliferative, anti-HIV, anti-convulsant, anti-inflammatory, anti-hypertensive, anti-neoplastic, proton pump inhibitor and anti-trichinellosis. The synthesis of benzimidazole derivatives remains a focus of medicinal research. Here benzimidazole derivatives were synthesized using two phase system under microwave conditions using the phase transfer catalyst tetra Bu ammonium chloride (10% mol) in good yield. The mol. docking study against 4GQQ protein with synthesized benzimidazole derivatives was performed to see the necessary interactions responsible for anti-bacterial activity. The experimental process involved the reaction of 2-Chloro-1H-benzo[d]imidazole(cas: 4857-06-1HPLC of Formula: 4857-06-1)
2-Chloro-1H-benzo[d]imidazole(cas: 4857-06-1) binds to monoclonal antibodies, inhibiting their binding to their corresponding antigens. This activity may be due to its ability to bind covalently with amino groups on proteins and other molecules.HPLC of Formula: 4857-06-1
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem